Evaluating the effects of antidepressant medication on post-operative outcomes in lower body contouring surgery after massive weight loss: A retrospective study.

Susanna Pajula, Esko Veräjänkorva, Virve Koljonen, Max Karukivi

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Article in JPRAS open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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4 authors.

Susanna PajulaDepartment of Plastic and General Surgery, Turku University Hospital, Kiinamyllynkatu 4-8, 20500 Turku, Finland.

Esko VeräjänkorvaHospital Mehiläinen-NEO, Turku Finland.

Virve KoljonenDepartment of Plastic Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Max KarukiviDepartment of Adolescent Psychiatry, University of Turku and Turku University Hospital, Turku, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Postoperative complications are common following lower body contouring surgery (LBCS) after massive weight loss (MWL). This study aimed to determine whether antidepressant use is associated with the occurrence of complications after LBCS. Materials and Methods: This retrospective study included consecutive patients who underwent LBCS after MWL at Turku University Hospital in Finland between 2016 and 2021. Weight loss was achieved either through bariatric surgery (BS) or lifestyle modifications. Results: A total of 150 patients were included, with a mean age of 45.8 ± 11.1 years. The majority were women, 128 (85.3 %), and 22 (14.7 %) were men. Most patients (71.3 %) underwent BS. Antidepressant use was reported in 33 patients (22 %). Compared to non-users, antidepressant users were older (49.1 vs. 44.8 years, Conclusion: Antidepressant use was associated with a higher risk of deep tissue infection. Whether these findings are due to the antidepressant or the underlying psychiatric condition remains unclear. Future studies should investigate the relative contributions of these factors to optimize the care of patients with a history of MWL who undergo LBCS.

Indexed as

Antidepressant medicationLower body contouring surgeryMassive weight lossPostoperative complications

Identifiers

PMID41215822

DOI10.1016/j.jpra.2025.09.018

PMCPMC12597044

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.