Evidence map›Paper›PMID 41215695›Full record

ReviewFuture science OA2025

Gut microbiome, stress and interventional strategies using hardy animals.

Ruqaiyyah Siddiqui, Rizwan Qaisar, Sutherland Maciver, Naveed Ahmed Khan

Abstract readReview
In one paragraph

Review in Future science OA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ruqaiyyah SiddiquiInstitute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University, Edinburgh, UK.
Rizwan QaisarResearch Institute of Medical and Health Sciences, University of Sharjah, University City, Sharjah, United Arab Emirates.
Sutherland MaciverInstitute for Neuroscience and Cardiovascular Research, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.
Naveed Ahmed KhanMicrobiota Research Center, Istinye University, Istanbul, Turkey.ORCID 0000-0001-7667-8553

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The composition of the gut microbiota has been linked to acute stressors, suggesting that modulation of the gut microbiome is a potential avenue for enhancing human health and performance. The gut microbiome exerts its effects through several metabolites, which induce epigenetic and metabolic changes. Stress is a common occurrence in humans facing challenging environments such as military personnel and astronauts, but is not limited to humans. Among various species, crocodiles are well known for their "hardiness" and ability to achieve longevity, while surviving under stressful conditions. We speculated that their microbial gut flora produces substances contributing to their ability to resist stress, "wellbeing" and "longevity". Herein, we deliberate upon the stressors faced by individuals in testing conditions, and discuss potential avenues that can mitigate the gut microbiome compositional changes in order to augment human performance and overall health.

Indexed as

circadian rhythmscrocodile microbiomeenvironmental stressGut microbiomehuman performanceresilient species

Identifiers

PMID41215695
PMCPMC12607289

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.