Trial reportJournal of cosmetic dermatology2025
Dietary Supplement With Cherry Blossom Flower and Rosa roxburghii Tratt Fruit Extract Improves Skin Aging: A Randomized, Placebo-Controlled, Blinded Clinical Study.
Trial report in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Dietary Supplement With Cherry Blossom Flower and Rosa roxburghii Tratt Fruit Extract Improves Skin Aging: A Randomized, Placebo-Controlled, Blinded Clinical Study.Journal of cosmetic dermatology · 2025Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe cherry blossom flower (sakura) and Rosa roxburghii Tratt (RRT) fruit demonstrate well-established antioxidant and anti-aging properties. However, their synergistic effects on skin aging remain understudied.
objectiveThis clinical study was designed to systematically evaluate the efficacy and safety of a dietary supplement containing sakura and RRT fruit extract in improving skin aging parameters.
methodsSixty healthy female participants aged 30-50 years were randomly allocated to receive a daily dietary supplement (150 mg sakura extract + 200 mg RRT fruit extract) or a placebo for 8 weeks. Primary outcomes- skin hydration, chromaticity, elasticity, collagen index, texture and scaliness, and wrinkles- were quantitatively assessed at baseline and week 8 using standardized instrumental methods.
resultsAfter 8 weeks of intervention, the dietary supplement significantly improved skin aging parameters versus placebo. Compared to before intervention, skin hydration increased by 28.07% (cheek) and 25.81% (forearm), significant improvement of skin chromaticity and elasticity on the cheek and inner forearm were observed (p < 0.01), and the mean collagen index rose by 1.8% (cheek) or 1.27% (inner forearm). Skin texture and scaliness reduction were presented. An evident reduction in the average volume and area ratio of skin wrinkles, including forehead wrinkles, crow's feet and nasolabial folds, were observed. There are reductions in neck line number (9.51%), neck line length (10.23%) and average depth of single neck line (7.14%).
conclusionsThe findings indicate that the sakura and RRT fruit extract complex is a safe and effective nutraceutical for mitigating skin aging.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.