Evidence map›Paper›PMID 41215657›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Heteromultivalent Nanogels as Highly Potent Inhibitors of Pseudomonas Aeruginosa.

Yuhang Jiang, Chuanxiong Nie, Boyu Zheng, Vinod Khatri, Denis Puccio, Yanping Long, Mathias Dimde, Rainer Haag, Sumati Bhatia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Heteromultivalent Nanogels as Highly Potent Inhibitors of Pseudomonas Aeruginosa.Angewandte Chemie (International ed. in English) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuhang JiangInstitute for Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 3, 14195, Berlin, Germany.ORCID 0009-0003-6570-245X
Chuanxiong NieInstitute for Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 3, 14195, Berlin, Germany.ORCID 0000-0001-7963-1187
Boyu ZhengInstitute for Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 3, 14195, Berlin, Germany.
Vinod KhatriInstitute for Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 3, 14195, Berlin, Germany.ORCID 0000-0002-7777-1984
Denis PuccioInstitute for Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 3, 14195, Berlin, Germany.
Yanping LongInstitute for Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 3, 14195, Berlin, Germany.
Mathias DimdeInstitute for Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 3, 14195, Berlin, Germany.
Rainer HaagInstitute for Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 3, 14195, Berlin, Germany.ORCID 0000-0003-3840-162X
Sumati BhatiaDepartment of Chemistry, Faculty of Science and Engineering, Swansea University, Swansea, SA2 8PP, UK.ORCID 0000-0002-5123-4937

Funding

Chinese Scholarship CouncilDeutsche Forschungsgemeinschaft 458564133Deutsche Forschungsgemeinschaft SFB 1449ERC 101055416HORIZON EUROPE European Research Council ERC grant SupraVir - Project Number: 101055416Royal Society of Chemistry RG∖R1∖241050
6 · The paper itself

Abstract

The increasing prevalence of microbial resistance requires new antibacterial concepts for selective targeting and killing of pathogenic bacteria. Here, we report the synthesis of a heteromultivalent nanogel system against Pseudomonas aeruginosa (P. aeruginosa). These nanogels are based on biocompatible polyglycerols and functionalized with sugar ligands fucose (Fuc) or galactose (Gal) for P. aeruginosa targeting. With a further modification of these nanogels with BMAP-18 short chain peptides (GRFKRFRKKFKKLFKKLS), we have achieved > 99.99% inactivation of planktonic and > 99.9% inactivation of biofilm-coated P. aeruginosa within 12 h of treatment. Additionally, the system demonstrates broad-spectrum antimicrobial potential, effectively inhibiting Escherichia coli (E. coli) and Methicillin-resistant Staphylococcus aureus (MRSA). This modular design offers a promising strategy for the development of next-generation antimicrobial therapies targeting biofilm-associated infections and MDR bacteria.

Indexed as

Anti-Bacterial AgentsPolyethylene GlycolsPseudomonas aeruginosaBiofilmsEscherichia coliMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsNanogelsAnti-Bacterial AgentsNanogelsPolyethylene GlycolsBacteria inactivationBiofilm dispersionHeteromultivalent nanogelsPseudomonas aeruginosa

Identifiers

PMID41215657
PMCPMC12723470

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.