Evidence map›Paper›PMID 41215620›Full record

ArticleAging cell2025

Long-Term Dietary Restriction Has a Strong and Positive Effect on Both Hepatic and Peripheral Insulin Sensitivity, in an Age- and Diet-Dependent Manner.

Joel C Fisher, Aaffien C Reijne, Kaja Hribar, Marcel A Vieira-Lara, Alzbeta Talarovicova, Dirk-Jan Reijngoud, David D van Niekerk, Jacky L Snoep, Gertjan van Dijk, Barbara M Bakker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Joel C FisherDepartment of Biochemistry, Stellenbosch University, Stellenbosch, South Africa.ORCID 0000-0002-5005-5267
Aaffien C ReijneGroningen Institute for Evolutionary Life Sciences, Department of Behavioral Neuroscience, University of Groningen, Groningen, the Netherlands.
Kaja HribarLaboratory of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Marcel A Vieira-LaraDepartment of Biotechnology, Delft University of Technology, Delft, HZ, the Netherlands.
Alzbeta TalarovicovaGroningen Institute for Evolutionary Life Sciences, Department of Behavioral Neuroscience, University of Groningen, Groningen, the Netherlands.
Dirk-Jan ReijngoudLaboratory of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
David D van NiekerkDepartment of Biochemistry, Stellenbosch University, Stellenbosch, South Africa.
Jacky L SnoepDepartment of Biochemistry, Stellenbosch University, Stellenbosch, South Africa.
Gertjan van DijkGroningen Institute for Evolutionary Life Sciences, Department of Behavioral Neuroscience, University of Groningen, Groningen, the Netherlands.
Barbara M BakkerLaboratory of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Funding

Ministry of Economic Affairs and Climate Policy of the NetherlandsNetherlands Organization for Scientific Research 853.00.110South African National Research Foundation NRF-SARCHI-82813
6 · The paper itself

Abstract

Dietary restriction (DR) improves insulin sensitivity, however, it has not been tested in long-term interventions and with diet type as variable. Therefore, we exposed mice to either a low-fat (LF) or high-fat-sucrose (HFS) diet, either fed ad libitum (AL) or in a DR regimen from weaning till 2 years of age. Using an oral glucose tolerance test with [6,6-

Indexed as

AgingCaloric RestrictionInsulin ResistanceLiverAnimalsDiet, High-FatGlucose Tolerance TestInsulinMaleMiceMice, Inbred C57BLInsulinageingdietdietary restrictionglucose homeostasisinsulin resistanceinsulin sensitivity

Identifiers

PMID41215620
PMCPMC12686546

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.