Evidence map›Paper›PMID 41215534›Full record

ArticleCell biochemistry and function2025

Alterations in Cardiovascular Parameters in 5xFAD Murine Model.

Andrea G Marshall, Dominique Stephens, Kit Neikirk, Sepiso K Masenga, Bryanna Shao, Amber Crabtree, Zer Vue, Heather K Beasley, Edgar Garza-Lopez, Estevão Scudese and 28 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell biochemistry and function, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Assessing cerebral capillary function and stalling using single capillary reporters in ultrasound localization microscopy.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

38 authors.

Andrea G MarshallDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0001-9997-4478
Dominique StephensDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Kit NeikirkDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Sepiso K MasengaDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0003-4376-5831
Bryanna ShaoDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Amber CrabtreeDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Zer VueDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Heather K BeasleyDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Edgar Garza-LopezDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
Estevão ScudeseDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Benjamin I RodriguezDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Han LeDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Steven DamoDepartment of Life and Physical Sciences, Fisk University, Nashville, Tennessee, USA.
George E TaffetDepartment of Medicine, Houston Methodist Hospital, Houston, Texas, USA.
Okwute M OchayiDepartment of Physiology, Faculty of Basic Medical Sciences, College of Medicine and Health Science, Baze University, Abuja, Federal Capital Territory, Nigeria.ORCID https://orcid.org/0000-0002-1468-5579
Ronald McMillanDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Jeremiah M AfolabiDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Vernat ExilDepartment of Pediatrics, Division of Cardiology, St. Louis University School of Medicine, St. Louis, Missouri, USA.
Ashton OliverVanderbilt Center for Immunobiology, Vanderbilt University, Nashville, Tennessee, USA.
Vineeta SharmaVanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University, Nashville, Tennessee, USA.
Pamela MartinDepartment of Biomedical Sciences, Meharry Medical College, Nashville, Tennessee, USA.
Amadou GayeDepartment of Cardiovascular Science and Metabolic Diseases, Livingstone Center for Prevention and Translational Science, Livingstone, Southern Province, Zambia.
Chanel HarrisDepartment of Biomedical Sciences, Meharry Medical College, Nashville, Tennessee, USA.
Briar TomeauDepartment of Biomedical Sciences, Meharry Medical College, Nashville, Tennessee, USA.
LaCara BellDepartment of Biomedical Sciences, Meharry Medical College, Nashville, Tennessee, USA.
Markis HamiltonDepartment of Biomedical Sciences, Meharry Medical College, Nashville, Tennessee, USA.
Taneisha GillyardDepartment of Biomedical Sciences, Meharry Medical College, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0002-4536-3724
Railyn WebsterDepartment of Biomedical Sciences, Meharry Medical College, Nashville, Tennessee, USA.
Marcus JacksonDepartment of Biomedical Sciences, Meharry Medical College, Nashville, Tennessee, USA.
Prem PrakashThe Center for AIDS Health Disparities Research (P.P., R.C., G.M., M.B., C.D.), Meharry, Medical College, Nashville, Tennessee, USA.
Shanilah FriersonDepartment of Biomedical Sciences, Meharry Medical College, Nashville, Tennessee, USA.
Chandravanu DashThe Center for AIDS Health Disparities Research (P.P., R.C., G.M., M.B., C.D.), Meharry, Medical College, Nashville, Tennessee, USA.
Margaret MungaiDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Annet KiraboDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Jennifer A GaddyDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Nelson WandiraDepartment of Public, Health School of Health Sciences Busoga University Iganga, Iganga, Eastern Region, Uganda.ORCID https://orcid.org/0009-0009-9063-0324
Antentor HintonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0002-7730-952X
Anilkumar K ReddyDepartment of Medicine, Houston Methodist Hospital, Houston, Texas, USA.

Funding

The RCMI Program in Health Disparities Research at Meharry Medical College - SupplementU54MD007586 · NIMHD · MEHARRY MEDICAL COLLEGE · PI Samuel Evans Adunyah · 2017 to 2026
$48.2M
Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3M
Tennessee CFAR: Implementation of Culturally Responsive Trauma-Informed Care with Youth with HIV in Memphis, TNP30AI110527 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI John Koethe · 2015 to 2026
$27.5M
MULTIDISCIPLINARY TRAINING IN MOLECULAR ENDOCRINOLOGYT32DK007563 · NIDDK · VANDERBILT UNIVERSITY · PI Richard M O'Brien · 1988 to 2026
$15.9M
PRIDE: Functional and Translational Genomics of Blood DisordersR25HL106365 · NHLBI · AUGUSTA UNIVERSITY · PI PACE, BETTY SUE · 2010 to 2024
$5.2M
Integrated Training in Engineering and DiabetesT32DK101003 · NIDDK · VANDERBILT UNIVERSITY · PI Jamey D. Young · 2014 to 2026
$3.9M
Role of GRIN2 in ART and SUD associated neurological deficits.R01DA057204 · NIDA · MEHARRY MEDICAL COLLEGE · PI Chandravanu Dash · 2022 to 2026
$3.7M
UNZA-Vanderbilt Training Partnership for HIV-NCD Research (UVP-2)D43TW009744 · FIC · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HEIMBURGER, DOUGLAS CORBETT, MUTALE, WILBROAD · 2015 to 2025
$3.2M
Spatiotemporal Staging of the HIV-1 Preintegration complexR01AI170228 · NIAID · MEHARRY MEDICAL COLLEGE · PI Chandravanu Dash · 2022 to 2026
$2.8M
Role of the Viral Capsid in HIV-1 IntegrationR01AI136740 · NIAID · MEHARRY MEDICAL COLLEGE · PI Chandravanu Dash · 2019 to 2026
$2.2M
Enhancing Virology Training of Underrepresented Minority Students through Summer ResearchR25AI164610 · NIAID · MEHARRY MEDICAL COLLEGE · PI DASH, CHANDRAVANU · 2021 to 2025
$1.8M
Salt taste sensitivity, genetics and salt sensitivity of blood pressure in HIVR21TW012635 · FIC · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KIRABO, ANNET, MASENGA, SEPISO KENIAS · 2023 to 2024
$385k
FIC NIH HHS D43 TW009744FIC NIH HHS R21 TW012635NHLBI NIH HHS R25 HL106365NIAID NIH HHS P30 AI110527NIAID NIH HHS R01 AI136740NIAID NIH HHS R01 AI170228NIAID NIH HHS R25 AI164610NIDA NIH HHS R01 DA057204NIDDK NIH HHS P30 DK020593NIDDK NIH HHS T32 DK007563NIDDK NIH HHS T32 DK101003NIMHD NIH HHS U54 MD007586This study is supported by National Institute of Health (NIH) NIDDK T-32, number DK007563 entitled Multidisciplinary Training in Molecular Endocrinology to Z.V.; The Fogarty International Center and National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health grants 2D43TW009744 and R21TW012635. The American Heart Association Award Number 24IVPHA1297559 (https://doi.org/10.58275/AHA.24IVPHA1297559.pc.gr.193866). The United Negro College Fund/Bristol-Myers Squibb E.E. Just Faculty Fund, Burroughs Wellcome Fund Career Awards at the Scientific Interface Award, Burroughs Wellcome Fund Ad-hoc Award, National Institutes of Health Small Research Pilot Subaward to 5R25HL106365-12 from the National Institutes of Health PRIDE Program, DK020593, Vanderbilt Diabetes and Research Training Center for DRTC Alzheimer's Disease Pilot & Feasibility Program to A.H.J. Its contents are solely the responsibility of the authors and do not necessarily represent the official view of the NIH. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
6 · The paper itself

Abstract

Alzheimer's Disease (AD) is a global health issue, affecting over 6 million people in the United States, with that number expected to increase as the population ages. As a neurodegenerative disorder that affects memory and cognitive functions, it is well established that AD is associated with cardiovascular risk factors beyond only cerebral decline. In this study, we measured hemodynamic parameters related to cardiovascular and cerebrovascular function in 5xFAD mice with AD and their littermates. Specifically, we measured cardiovascular pulse wave velocity parameters, a marker of arterial stiffness and cardiovascular risk, and cerebrovascular pulse wave velocity, a novel technique to measure cerebral arterial stiffness. Our results showed that while 5xFAD mice exhibited significant differences in ejection time, pulse pressure, and Tei index, many other cardiovascular and cerebral parameters were not different. Despite reports that amyloid plaque deposition begins at an early age of 1.5 months in 5xFAD mice, our results did not indicate significant cardiovascular changes. Studies to elucidate cardiovascular and cerebrovascular parametric changes should be done at later ages where the underlying changes are more profound.

Indexed as

Alzheimer DiseaseAnimalsCardiovascular DiseasesDisease Models, AnimalMaleMiceMice, TransgenicPulse Wave AnalysisVascular Stiffness5xFADalzheimer's diseasecardiovascular diseasepulse wave velocity

Identifiers

PMID41215534
PMCPMC12603476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.