A three-step, one-pot strategy to unsymmetrical 1,1-diarylalkenes.

Vijayaragavan Elumalai, Hanna Bähr, Karoline Nordli, Stian R Martinsen, Cole Funk, Jørn H Hansen

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Article in BMC research notes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Vijayaragavan ElumalaiDepartment of Chemistry, UiT The Arctic University of Norway, Chemical Synthesis and Analysis Group, 9037, Tromsø, Norway.

Hanna BährDepartment of Chemistry, UiT The Arctic University of Norway, Chemical Synthesis and Analysis Group, 9037, Tromsø, Norway.

Karoline NordliDepartment of Chemistry, UiT The Arctic University of Norway, Chemical Synthesis and Analysis Group, 9037, Tromsø, Norway.

Stian R MartinsenDepartment of Chemistry, UiT The Arctic University of Norway, Chemical Synthesis and Analysis Group, 9037, Tromsø, Norway.

Cole FunkDepartment of Chemistry, UiT The Arctic University of Norway, Chemical Synthesis and Analysis Group, 9037, Tromsø, Norway.

Jørn H HansenDepartment of Chemistry, UiT The Arctic University of Norway, Chemical Synthesis and Analysis Group, 9037, Tromsø, Norway. jorn.h.hansen@uit.no.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveDevelop a one-pot, three-step procedure for effective access to diverse unsymmetrical 1,1-diarylalkenes from readily accessible reagents, catalysts and substrates.

resultsA three-step, one-pot procedure for the synthesis of unsymmetrical 1,1-diarylalkenes via a dibromination-elimination-Suzuki Miyaura coupling sequence has been designed and a range of reaction conditions have been screened. Although high selectivities can be achieved in some cases, the overall reaction typically proceeds in low to moderate isolated yields albeit up to 70% was observed. The reaction is compatible with a range of substituent patterns on the arylboronic acid and different styrenes.

Indexed as

AlkenesBoronic AcidsCatalysisAlkenesBoronic Acids1,1-DiarylalkenesDibrominationOne-pot procedureSuzuki-Miyaura coupling

Identifiers

PMID41214752

DOI10.1186/s13104-025-07553-0

PMCPMC12604287

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