Evidence map›Paper›PMID 41214731›Full record

ArticleMalaria journal2025

Isolation, identification and characterization of compounds from the n-hexane fraction of Citrus limon seeds: cytotoxic and mosquito repellent activities.

Mukaram Akintunde Adeniyi-Akee, Emmanuel Oloruntoba Yeye, Adibe Kingsley Mbachu, Kolade Ibrahim, Ogunyemi Oderinlo, Paul Matthew Osamudiamen, Sunday Olakunle Idowu, Olapeju O Aiyelaagbe, Olajire Aremu Adegoke

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Article in Malaria journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Mukaram Akintunde Adeniyi-AkeeDepartment of Pharmaceutical Chemistry, College of Pharmacy, Igbinedion University, Okada, Edo State, Nigeria. mukkyakee@yahoo.com.
Emmanuel Oloruntoba YeyeDepartment of Chemistry, Faculty of Science, University of Ibadan, Ibadan, Nigeria.
Adibe Kingsley MbachuDepartment of Chemistry, Faculty of Science, University of Ibadan, Ibadan, Nigeria.
Kolade IbrahimDepartment of Zoology, Faculty of Science, University of Ibadan, Ibadan, Nigeria.
Ogunyemi OderinloDepartment of Chemistry, Federal University, Otuoke, Bayelsa State, Nigeria.
Paul Matthew OsamudiamenDepartment of Chemical Sciences, Bells University of Technology, Ota, Lagos State, Nigeria.
Sunday Olakunle IdowuDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Ibadan, Ibadan, Nigeria.
Olapeju O AiyelaagbeDepartment of Chemistry, Faculty of Science, University of Ibadan, Ibadan, Nigeria.
Olajire Aremu AdegokeDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Ibadan, Ibadan, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prevalence of malaria and other mosquito menace in Lagos State and many other parts of Nigeria has becomes so alarming. Citrus limon seeds have limited exploration, unlike the leaves, juice and the peels which are burnt as repellent and have been widely explored. This study was conducted to evaluate the repellent and cytotoxic effects of three known lipids, a known flavonoid and a novel fatty acid isolated from the n-hexane fraction C. limon.

methodsThe structures of the compounds were determined based on spectroscopic (IR, 1-D, 2-D NMR) and mass spectrometric experiments. Isolated compounds were evaluated for cytotoxicity and Anopheles gambiae mosquito repellent effects, using brine shrimp lethality assay (safety cut-off, LC

resultsCompounds 1-5 identification gave, Palmitic acid (1), 14-Oxotricosanoic acid (2), n-Octyl stearate (3), 4-heptadec-7-enyloxy)carbonyl)butanoic acid (4) and 6,8 dimethoxy-3-undecyl-1H-[2]benzopyran-1-one (5). Compounds (1, 2 and 4) showed some level of toxicity with LC

conclusionThe results offer additional scientific justification for the local usage of Citrus limon as mosquito repellent.

Indexed as

AnophelesCitrusInsect RepellentsPlant ExtractsSeedsAnimalsArtemiaHexanesNigeriaHexanesInsect Repellentsn-hexanePlant ExtractsAnopheles gambiaeArtemiCitrus limonCytotoxicityRepellent activity

Identifiers

PMID41214731
PMCPMC12604279

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