Evidence map›Paper›PMID 41214722›Full record

ArticleGenome biology2025

Translational regulation plasticity shapes wheat grain adaptation to heat stress.

Yongming Chen, Yiwen Guo, Mengsi Ma, Yongfa Wang, Weilong Guo, Zhaorong Hu, Mingming Xin, Yingyin Yao, Zhongfu Ni, Qixin Sun and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yongming Chen *Frontiers Science Center for Molecular Design Breeding, Key Laboratory of Crop Heterosis and Utilization, Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, 100193, China.
Yiwen Guo *Frontiers Science Center for Molecular Design Breeding, Key Laboratory of Crop Heterosis and Utilization, Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, 100193, China.
Mengsi MaFrontiers Science Center for Molecular Design Breeding, Key Laboratory of Crop Heterosis and Utilization, Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, 100193, China.
Yongfa WangFrontiers Science Center for Molecular Design Breeding, Key Laboratory of Crop Heterosis and Utilization, Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, 100193, China.
Weilong GuoFrontiers Science Center for Molecular Design Breeding, Key Laboratory of Crop Heterosis and Utilization, Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, 100193, China.
Zhaorong HuFrontiers Science Center for Molecular Design Breeding, Key Laboratory of Crop Heterosis and Utilization, Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, 100193, China.
Mingming XinFrontiers Science Center for Molecular Design Breeding, Key Laboratory of Crop Heterosis and Utilization, Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, 100193, China.
Yingyin YaoFrontiers Science Center for Molecular Design Breeding, Key Laboratory of Crop Heterosis and Utilization, Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, 100193, China.
Zhongfu NiFrontiers Science Center for Molecular Design Breeding, Key Laboratory of Crop Heterosis and Utilization, Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, 100193, China.
Qixin SunFrontiers Science Center for Molecular Design Breeding, Key Laboratory of Crop Heterosis and Utilization, Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, 100193, China.
Huiru PengFrontiers Science Center for Molecular Design Breeding, Key Laboratory of Crop Heterosis and Utilization, Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, 100193, China. penghuiru@cau.edu.cn.

Funding

National Natural Science Foundation of China 31971942National Natural Science Foundation of China 32130078National Natural Science Foundation of China 32401854Pinduoduo-China Agricultural University Research Fund PC2024A01002
6 · The paper itself

Abstract

backgroundExtremely high temperatures due to global warming are increasingly threatening crop production, and plants have evolved highly sophisticated mechanisms to respond to harsh environmental stresses and survive. At the translational level, how bread wheat responds to high temperatures remains largely unknown.

resultsWe use ribosome profiling and high-throughput sequencing to investigate the translatome of wheat grains in response to high temperatures. Our study reveals that heat stress profoundly reshapes the translatomic landscapes, significantly affecting the translation of the mRNAs involved in the translation process, grain development, and heat stress response. A subset of the upstream open reading frames (uORFs) and RNA-binding proteins specifically link to their potential target with associated translatomic changes under high temperature. Divergent translation of duplicated genes is affected by the imbalanced expression of uORFs. Interestingly, the high temperature stimulates expression of small ORFs in long non-coding RNAs (lORFs). Microproteins encoded by key heat-responsive lORFs localize to cellular regions including the nucleus, endoplasmic reticulum, and P-body, and interact with heat shock proteins. Furthermore, the microprotein and RNA-binding protein contribute to the heat tolerance variation among wheat accessions.

conclusionsThis study provides new insights into the translational regulatory mechanism in wheat heat tolerance, accelerating genetic improvements in crops for optimal climate resilience.

Indexed as

Adaptation, PhysiologicalGene Expression Regulation, PlantHeat-Shock ResponseProtein BiosynthesisTriticumEdible GrainOpen Reading FramesPlant ProteinsRibosomesRNA-Binding ProteinsRNA, Long NoncodingPlant ProteinsRNA-Binding ProteinsRNA, Long NoncodingBread wheatHeat stressMicroproteinTranslational regulationuORF

Identifiers

PMID41214722
PMCPMC12599102

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.