ArticleDiabetology & metabolic syndrome2025
Prevalence of coexisting diabetes and depression and the association of urinary albumin with all-cause and cardiovascular mortality in affected individuals: a National population-based study.
Article in Diabetology & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionIndividual who have both diabetes and depression are at a higher risk of experiencing adverse health outcomes. However, the association between urine albumin levels and mortality in individuals with both diabetes and depression has not been examined. MATERIALS AND
methodsWe estimate the prevalence of coexisting diabetes and depression within the National Health and Nutrition Examination Survey (NHANES) cohort. Subsequently, we examined the association between urinary protein levels and both all-cause and cardiovascular mortality in this population. Individuals were divided into three groups based on urinary protein concentrations: Quantile 1 to Quantile 3.
resultsThe prevalence of coexisting diabetes and depression was found to be 1.91%, rising from 1.07% in 2005 to 2.11% in 2018. During a median follow-up period of 75 months, the all-cause mortality in Quantiles 1, 2, and 3 were 50 (11.26%), 60 (17.17%), and 106 (29.22%) cases, respectively (p < 0.001). Cardiovascular mortality was also higher in Quantile 2 (6.30%) and Quantile 3 (7.54%) compared to Quantile 1 (1.66%). After adjusting for potential confounding factors, elevated urine albumin levels remained independently related to a higher risk of all-cause mortality (Quantile 3 vs. Quantile 1: HR = 3.04, 95% CI: 1.71 to 5.39) as well as cardiovascular mortality (Quantile 3 vs. Quantile 1: HR = 3.55, 95% CI: 1.44 to 8.76).
conclusionsThe prevalence of concurrent diabetes and depression has risen notably, and higher urine albumin levels are independently related to a high risk of both all-cause and cardiovascular mortality in individuals who have both conditions.
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