Evidence map›Paper›PMID 41214708›Full record

ArticleAIDS research and therapy2025

Community-based enhanced adherence counseling among people living with HIV in Ethiopia: outcomes and key predictors of viral suppression.

Endris Seid Ebrahim, Dawit A Tsegaye, Gashaw A Biks, Fisseha Shiferie, Liyu Wegayehu, Asayehegn Tekeste, Gobena Seboka, Ambachew Tefera, Legese A Mekuria, Adrienne Hayes and 6 more

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Article in AIDS research and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

16 authors.

Endris Seid EbrahimCommunity HIV Care and Treatment Activity, Project HOPE, P. O. Box 45, Addis Ababa, Ethiopia. eseid@projecthope.org.
Dawit A TsegayeCommunity HIV Care and Treatment Activity, Project HOPE, P. O. Box 45, Addis Ababa, Ethiopia.
Gashaw A BiksCommunity HIV Care and Treatment Activity, Project HOPE, P. O. Box 45, Addis Ababa, Ethiopia.
Fisseha ShiferieCommunity HIV Care and Treatment Activity, Project HOPE, P. O. Box 45, Addis Ababa, Ethiopia.
Liyu WegayehuCommunity HIV Care and Treatment Activity, Project HOPE, P. O. Box 45, Addis Ababa, Ethiopia.
Asayehegn TekesteCommunity HIV Care and Treatment Activity, Project HOPE, P. O. Box 45, Addis Ababa, Ethiopia.
Gobena SebokaCommunity HIV Care and Treatment Activity, Project HOPE, P. O. Box 45, Addis Ababa, Ethiopia.
Ambachew TeferaCommunity HIV Care and Treatment Activity, Project HOPE, P. O. Box 45, Addis Ababa, Ethiopia.
Legese A MekuriaCommunity HIV Care and Treatment Activity, Project HOPE, P. O. Box 45, Addis Ababa, Ethiopia.
Adrienne HayesGlobal Health, Project HOPE, Washington D.C., USA.
Wondwossen A AlemayehuGlobal Health, Project HOPE, Washington D.C., USA.
Endalkachew MeleseGlobal Health, Project HOPE, Washington D.C., USA.
Joseph OduGlobal Health, Project HOPE, Washington D.C., USA.
Sangeeta MookherjiGlobal Health, Project HOPE, Washington D.C., USA.
Emily LiddellGlobal Health, Project HOPE, Washington D.C., USA.
Afework NegashHIV Prevention, Care and Treatment, PEPFAR/USAID, Addis Ababa, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCommunity-based enhanced adherence counseling (CEAC) is person-centered intervention provided to PLHIV on ART and with unsuppressed viral load (VL) in community settings. This study assessed the effectiveness of CEAC in achieving viral load suppression (VLS) and explored key predictors to inform scalable strategies in resource-limited settings.

methodsA quantitative, retrospective follow-up study was conducted between October 2022 and October 2024 on 2839 PLHIVs enrolled to CEAC service. Study participants were HIV-infected individuals who were on ART for at least six months and had unsuppressed VL. Frontline community health workers provided them with three-to-six monthly sessions of counseling to address underlying barriers to treatment adherence. Client-level data were collected using CommCare mobile app and analyzed in SPSS.

resultsA total of 2839 PLHIV were enrolled in CEAC, of which 2365 (83.3%; 95% CI: 82.0-84.5%) clients achieved VLS after receiving three-to-six months of CEAC. Major significant predictors of VLS included age 1-14 years [AOR (95% CI) = 2.08 (1.25-3.41)], having a baseline VL of < 10,000 copies/mL [AOR (95% CI) = 1.75 (1.41-2.17)], and enrolled to other community-based case management services [AOR (95% CI) = 5.77 (4.33-7.71)]. Moreover, PLHIV with adherence related challenges resolved had higher odds of VLS [AOR = 1.86; 95%CI: 1.48 - 2.34].

conclusionCEAC service demonstrated encouraging results in supporting VLS among PLHIVs on ART with unsuppressed VL count. Community-based interventions showed potential in addressing individual barriers that were challenging to health facility to improve VLS. We recommend continuing efforts to scale up and integrate CEAC with ongoing health facility EAC services to synergistically improve VLS and accelerate epidemic control.

Indexed as

Anti-HIV AgentsCounselingHIV InfectionsMedication AdherenceAdolescentAdultCommunity Health ServicesEthiopiaFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesViral LoadYoung AdultAnti-HIV AgentsCommunity-basedEnhanced adherence counselingHIV/AIDSHIV careViral load suppression

Identifiers

PMID41214708
PMCPMC12604243

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.