ArticleJournal of nanobiotechnology2025
Multifunctional metal-phenolic network coatings drive immunocompetent osseointegration via marrow microenvironment remodeling.
Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- A xenogeneic developmental matrix hydrogel with MnOBioactive materials · 2026Article
- Mechanism-Driven Design of Metal-Phenolic Networks: From Precision Assembly to Multidimensional Synergistic Therapy for Brain Diseases.Pharmaceutics · 2026Review
- Versatile metal-phenolic network structure (MPNs) as advanced delivery platforms for bioactive compounds: The design principles, foundations, applications, and future perspectives.Materials today. Bio · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Surface modification is crucial for improving bone-implant integration, but current coating technologies lack simplicity, efficiency, and multifunctionality needed for clinical use. Metal-phenolic networks (MPNs) are emerging as a promising biomaterial interface that addresses osseointegration challenges through precise physicochemical design. Our study introduces a gallic acid-arginine@zinc (GA-Arg@Zn) MPN coating that promotes favorable host responses in the following ways: (1) Immunomodulation: Shifting macrophages towards CD206+ anti-inflammatory phenotypes while reducing TNF-α, IL-1β, and IL-6 secretion to create an immunoregulatory environment that minimizes fibrous encapsulation. (2) Osteopromotion: Enhancing bone marrow stromal cell (BMSC) osteogenic differentiation by increasing ALP activity and OCN expression through modulation of the ionic microenvironment. (3) Biointerface Engineering: Establishing an immunologically favorable osteogenic microenvironment that boosts BMSC recruitment and mineralization capacity through paracrine signals from macrophages. This self-reinforcing “immuno-osseous” regenerative axis integrates material-induced immunomodulation with stem cell activation, representing a significant advancement in orthopedic interface engineering. The coating’s rapid aqueous deposition and inherent antibacterial properties further highlight its clinical promise.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.