SynthesisBMC pregnancy and childbirth2025
Incidence of pregnancy outcomes among patients with recurrent implantation failure: a systematic review and meta-analysis.
Synthesis in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of acupuncture for recurrent implantation failure: a systematic review and meta-analysis of randomized controlled trials.Frontiers in medicine · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundGlobally, there is no conclusive data on the pregnancy outcomes of patients with recurrent implantation failure (RIF) who received the next embryo transfer. The purpose of this study is to summarize the pregnancy outcomes of patients with RIF after embryo transfer and understand the disease burden of patients with RIF.
methodsWe searched for literature from databases such as PubMed, Web of Science, Embase, and Cochrane Central Register of Controlled Trials from inception to May 19, 2024, and extracted the pregnancy outcomes of patients with RIF in the blank control group, including implantation rate (IR), clinical pregnancy rate (CPR), ongoing pregnancy rate (OPR), miscarriage rate (MR), live birth rate (LBR), and ectopic pregnancy rate (EPR). Subsequently, meta-analyses of the rates were summarized and subgroup analyses were performed based on implantation failures, embryo type, fresh/frozen embryo transfer and regions.
resultsA total of 110 studies (14,159 patients) were included in the meta-analysis. Globally, the overall IR, CPR, OPR, MR, LBR, and EPR of patients with RIF were 19.3%, 29.4%, 24.6%, 19.9%, 23.0%, and 0.9%, respectively. No differences in pregnancy outcomes were found between RIF patients with three or more implantation failures and those with two or more implantation failures. RIF patients who transferred blastocyst achieved significantly higher IR, higher CPR, higher OPR, higher LBR and lower EPR, but no lower MR. There are differences in IR and CPR among patients with RIF in different regions, and no significant differences in other pregnancy outcomes.
conclusionThis study summarizes the global pregnancy outcomes of patients with RIF who undergo subsequent embryo transfer. Pregnancy outcomes in patients with RIF may not be related to the number of implantation failures. Frozen blastocyst transfer is recommended for patients with RIF. Pregnancy outcomes in patients with RIF vary across regions. PROTOCOL REGISTRATION: This study has been registered on PROSPERO (CRD 42024539968).
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