SynthesisBMC geriatrics2025
The comprehensive impact of exercise interventions on cognitive function and quality of life in alzheimer's disease patients: a systematic review and meta-analysis.
Synthesis in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Dual-task versus single-task walking within an Otago Exercise Program for older adults with dementia: A 24-week cluster randomized controlled trial.Journal of exercise science and fitness · 2026Article
- Exercise-induced neuropeptidergic and neurochemical neuroadaptation in stress regulation and emotional disorders.Acta neurologica Belgica · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlzheimer's Disease (AD) is a progressive neurodegenerative disorder marked by cognitive decline and reduced quality of life. Exercise interventions are considered a promising non-pharmacological strategy to enhance cognition and well-being in AD patients. However, effects across different cognitive domains and quality of life remain unclear due to variations in study designs, intervention types, and outcome measures.
objectiveThis systematic review and meta-analysis evaluated the effects of exercise interventions on cognitive function, executive function, memory, and quality of life in AD patients by synthesizing evidence from randomized controlled trials (RCTs).
methodsWe conducted a comprehensive search in PubMed, Embase, and Web of Science. Forty-five studies met inclusion criteria and were included in the quantitative synthesis. Primary outcomes included global cognition, executive function, memory, and quality of life. Meta-analyses were performed using standardized mean differences (SMD) and 95% confidence intervals (CI). Risk of bias was assessed via the Cochrane tool, and heterogeneity was quantified using the I² statistic.
resultsExercise interventions Significantly improved global cognition, with SMDs of 0.30 (95% CI: 0.17-0.43, p < 0.00001) for MMSE and 0.39 (95% CI: 0.08-0.70, p = 0.01) for MoCA, with low heterogeneity (I² = 36% and 0%). ADAS-Cog showed a small, non-significant effect (SMD = - 0.09, 95% CI: - 0.35 to 0.17, p = 0.49). Executive function (SMD = 0.13, p = 0.09) and memory (SMD = 0.09, p = 0.34) did not improve significantly. Quality of life improved significantly (SMD = 0.17, 95% CI: 0.03-0.31, p = 0.02; I² = 5%), measured using tools such as QOL-AD and Qualidem.
conclusionEvidence suggests that structured, multimodal exercise programs-combining aerobic (≥ 150 min/week), resistance (2-3 times/week), and balance training (2-3 times/week) for at least 12 weeks with individualized intensity-may improve global cognition and quality of life in Alzheimer's disease patients.
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