Evidence map›Paper›PMID 41214462›Full record

ArticleJournal of psychoactive drugs2025

Psychedelic Augmentation of 12-Step Engagement: A Novel, Accessible Approach to Enhance Community-Based Recovery from Substance Use Disorders.

Nicky J Mehtani, Maha N Mian, Gabrielle Agin-Liebes, Allison R Coker, Christopher Huebner, Brian T Anderson, Jennifer M Mitchell

Abstract read
In one paragraph

Article in Journal of psychoactive drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nicky J MehtaniDepartment of Medicine, University of California, San Francisco, CA, USA.ORCID 0000-0003-4277-6889
Maha N MianDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.ORCID 0000-0001-7051-7820
Gabrielle Agin-LiebesDepartment of Psychiatry, Yale University, New Haven, CT, USA.ORCID 0000-0002-9754-229X
Allison R CokerDepartment of Neurology, University of California, San Francisco, CA, USA.ORCID 0000-0001-5353-4653
Christopher HuebnerDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.
Brian T AndersonDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.ORCID 0000-0001-5023-660X
Jennifer M MitchellDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.ORCID 0000-0002-7567-8129

Funding

Institutional Career Development Core SupplementKL2TR001870 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M., SARKAR, URMIMALA · 2016 to 2025
$19.7M
Substance Use Disorders Treatment/Services Research Training ProgramT32DA007250 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Derek D Satre, Janice Y Tsoh · 1991 to 2026
$7.4M
NCATS NIH HHS KL2 TR001870NIDA NIH HHS T32 DA007250
6 · The paper itself

Abstract

Amid an evolving psychedelic drug policy landscape and limitations of existing substance use disorder (SUD) treatments, a novel addiction recovery paradigm has emerged involving augmentation of 12-Step program engagement with therapeutic psychedelic use. A preliminary qualitative analysis was initiated to describe this movement by examining real-world experiences of participants in remission from alcohol, opioid, and stimulant use disorders. Between November 2022 and February 2023, data collection was piloted with nine individuals reporting ayahuasca, ibogaine, psilocybin, and/or peyote use in combination with 12-Step engagement. Participants were intentionally recruited through a community partner to explore this emerging phenomenon; findings are not intended to generalize to broader 12-Step communities. Motivations included challenges with sobriety, psychological distress during abstinence, dissatisfaction with existing SUD treatments, and the relative accessibility of this community-based approach compared to clinical care. Participants highlighted reduced SUD-related cravings, psychospiritual mechanisms of behavior change, and synergistic effects of psychedelics with Steps 2, 4, and 11. Tensions with abstinence-oriented philosophies were acknowledged, and risks related to unsupervised psychedelic use were central to participants' narratives; however, participants ultimately found that psychedelics enhanced their recovery by deepening actionable Step-work and improving psychosocial well-being. Pilot findings underscore a need for further research into this low-cost, accessible approach.

Indexed as

12-Step recoveryaddictioncommunity-based treatmentPychedelicssubstance use disorders

Identifiers

PMID41214462
PMCPMC12646296

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.