Evidence map›Paper›PMID 41214415›Full record

ArticleJournal of medical toxicology : official journal of the American College of Medical Toxicology2026

The Donovan Memorial Lecture: 'Fentanyl-Plus': A New Era of Fentanyl Polydrug Combinations in the North American Overdose Crisis.

Daniel Ciccarone

Abstract readLecture
In one paragraph

Article in Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Daniel CiccaroneDepartment of Family and Community Medicine, University of California San Francisco, San Francisco, CA, USA. Daniel.Ciccarone@ucsf.edu.ORCID http://orcid.org/0000-0002-2355-5477

Funding

Synthetics in Combination (SYNC)R01DA054190 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DANIEL H CICCARONE · 2021 to 2026
$4.3M
Tranq Burn: the acidity of xylazine and fentanyl combinationsR21DA064011 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DANIEL H CICCARONE · 2025 to 2026
$455k
NIDA NIH HHS DA054190NIDA NIH HHS R01 DA054190NIDA NIH HHS R21 DA064011
6 · The paper itself

Abstract

The 2025 ACMT Ward and Ryan Donovan Memorial Fund lecture was presented by Daniel Ciccarone, MD, MPH from Department of Family and Community Medicine at the University of California San Francisco (UCSF). This article is an edited version of his keynote address during ACMT's 2025 Annual Scientific Meeting. During the course of his talk, Dr. Ciccarone discussed polysubstance use in the "Fentanyl-plus" era. The epidemiology and economics of the four waves of opioid overdose deaths were examined, and promising harm reduction strategies to assist in reducing overdose mortality were highlighted.

Indexed as

Analgesics, OpioidDrug OverdoseFentanylOpiate OverdoseOpioid-Related DisordersHarm ReductionHumansAnalgesics, OpioidFentanylFentanylOpioidsPolysubstance useStimulantsXylazine

Identifiers

PMID41214415
PMCPMC12834897

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.