SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025
Prognostic and diagnostic utility of heart rate variability to predict and understand change in cancer and chemotherapy related fatigue, pain, and neuropathic symptoms: a systematic review.
Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAdvances in early cancer detection and treatment have significantly improved survival rates, resulting in over 18.1 million cancer survivors in the USA. Many of these survivors experience chronic pain, fatigue, and neuropathic symptoms related to cancer or its treatments. Emerging evidence suggests that autonomic nervous system dysfunction plays a crucial role in these symptoms. Heart rate variability (HRV), a measure of autonomic function, has shown potential in predicting the onset and progression of these cancer-related symptoms. This systematic review aimed to assess the association of HRV with pain, fatigue, and neuropathy in cancer patients and survivors.
methodsA comprehensive search was conducted across multiple databases, yielding 23 studies that met inclusion criteria. These studies varied in cancer types, stages, and HRV measurement methods.
resultsMost studies focused on breast cancer and reported a predominant female population. Fatigue was the most studied symptom (n = 15), followed by pain (n = 7), and only one study assessed neuropathic symptoms. HRV measures included both time and frequency domain variables, with significant variability in measurement duration and control for confounding factors.
conclusionFindings suggest that decreased HRV is associated with increased fatigue and pain, providing potential support for a bidirectional relationship between autonomic dysfunction and these symptoms. However, the heterogeneity in HRV measurement methods and the high risk of bias in many studies highlight the need for high-quality prospective and interventional studies with standardized HRV protocols in cancer research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.