Article in EMBO reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Jinming GaoDepartment of Biomedical Engineering, UT Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-0726-5098
Trudy G OliverDepartment of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.ORCID 0000-0003-2082-2397
Kathryn A O'DonnellDepartment of Molecular Biology, UT Southwestern Medical Center, Dallas, TX, USA. Kathryn.ODonnell@UTSouthwestern.edu.ORCID 0000-0003-2215-1064
Funding
UNIVERSITY OF TEXAS--SPORE IN LUNG CANCERP50CA070907 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI HEYMACH, JOHN V. · 1996 to 2024
$57.4M
UT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Kathryn Ann O'Donnell · 2010 to 2026
$53.7M
Coordinating center for the NCI small cell lung cancer research consortiumU24CA213274 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Lauren Averett Byers, JOHN D. MINNA · 2017 to 2026
$12.9M
Pro-tumor functions of neutrophils in squamous cell lung cancerR01CA244841 · NCI · UNIVERSITY OF UTAH · PI OLIVER, TRUDY GALE · 2020 to 2024
$2.0M
The role of PCDH7 in lung cancer pathogenesisR01CA207763 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI O'DONNELL, KATHRYN ANN · 2017 to 2021
$2.0M
The role of translation initiation factor eIF5B in lung cancer pathogenesisR01CA273585 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Kathryn Ann O'Donnell · 2023 to 2026
$1.9M
Molecubes PET/CT systemS10OD032303 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI LU, WEIGUO · 2022 to 2022
$600k
High-performance slide scanner for multichannel fluorescence, brightfield and polarizationS10OD032267 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI RAMIREZ, DENISE MARIE · 2022 to 2022
$208k
American Lung Association (ALA) LCD1421064Cancer Prevention and Research Institute of Texas (CPRIT) RP190610Cancer Prevention and Research Institute of Texas (CPRIT) RP200327Cancer Prevention and Research Institute of Texas (CPRIT) RP250391Cancer Prevention and Research Institute of Texas (CPRIT) RP250572HHS | NIH | National Cancer Institute (NCI) P50CA70907HHS | NIH | National Cancer Institute (NCI) R01CA207763HHS | NIH | National Cancer Institute (NCI) R01CA244841-05HHS | NIH | National Cancer Institute (NCI) R01CA273585HHS | NIH | National Cancer Institute (NCI) U24CA213274NCI NIH HHS P30 CA142543NCI NIH HHS P50 CA070907NCI NIH HHS R01 CA207763NCI NIH HHS R01 CA244841NCI NIH HHS R01 CA273585NCI NIH HHS U24 CA213274NIH HHS S10 OD032267NIH HHS S10 OD032303U.S. Department of Defense (DOD) LC190249V Foundation for Cancer Research (VFCR) T2021-011Welch Foundation (The Welch Foundation) I-1881
6 · The paper itself
Abstract
Lung cancer is the leading cause of cancer-related deaths worldwide. Existing therapeutic options have limited efficacy, particularly for lung squamous cell carcinoma (LUSC), underscoring the critical need for the identification of new therapeutic targets. We previously demonstrated that the Transmembrane Serine Protease TMPRSS11B promotes the transformation of human bronchial epithelial cells and enhances lactate export from LUSC cells. Here, we evaluate the impact of TMPRSS11B activity on the host immune system and the tumor microenvironment (TME). Tmprss11b depletion significantly reduces tumor burden in immunocompetent mice and triggers an infiltration of immune cells. RNA FISH analysis and spatial transcriptomics in the autochthonous Rosa26-Sox2-Ires-Gfp
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
TMPRSS11B promotes an acidified microenvironment and immune suppression in squamous lung cancer. · full record | OpenQuestion