Evidence map›Paper›PMID 41214333›Full record

ReviewNature reviews. Molecular cell biology2025

Mechanistic insights into cargo sorting and export from the Golgi apparatus.

Emma T Watson, William R Wegeng, Stamatina Aravani, Andreas M Ernst, Julia von Blume

Abstract readReview
In one paragraph

Review in Nature reviews. Molecular cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Emma T Watson *Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-5336-8170
William R Wegeng *Department of Cell and Developmental Biology, School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
Stamatina AravaniDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0009-0000-0504-510X
Andreas M Ernst *Department of Cell and Developmental Biology, School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA. aernst@ucsd.edu.ORCID http://orcid.org/0000-0001-7359-7184
Julia von Blume *Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA. julia.vonblume@yale.edu.ORCID http://orcid.org/0000-0001-6665-1592

Funding

Pathways in Biological Sciences Training ProgramT32GM133351 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Matthew Daugherty, Randolph Y. Hampton · 2020 to 2026
$9.9M
DIABETES MELLITUS &DISORDERS OF METABOLISMT32DK007058 · NIDDK · YALE UNIVERSITY · PI SONIA CAPRIO, Kevan C Herold · 1986 to 2026
$9.6M
Coordinating Unit for the Innovative Science Accelerator ProgramU24DK128851 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2021 to 2025
$6.7M
Morphological Determinants of Intracellular Membrane CompartmentsR35GM142433 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andreas Max Ernst · 2021 to 2026
$2.2M
Mechanism of secretory cargo sorting at the trans-Golgi Network (TGN)R35GM149293 · NIGMS · YALE UNIVERSITY · PI Julia von Blume · 2023 to 2026
$1.6M
In situ cryo-EM of protein condensates in the early secretory pathway of neuronsR21DA061421 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ERNST, ANDREAS MAX, VILLA, ELIZABETH · 2024 to 2025
$437k
NIDA NIH HHS R21 DA061421NIDDK NIH HHS T32 DK007058NIDDK NIH HHS U24 DK128851NIGMS NIH HHS R35 GM142433NIGMS NIH HHS R35 GM149293NIGMS NIH HHS T32 GM133351
6 · The paper itself

Abstract

The Golgi apparatus has a central role in the formation and trafficking of glycoproteins and lipids. It is organized into a series of flattened, membrane-bound compartments called cisternae, each housing a unique set of resident proteins that sequentially modify newly synthesized proteins and lipids as they move through the Golgi stack. In the final compartments, known as the trans-Golgi network (TGN), the processed cargoes are sorted and packaged into transport carriers. Despite substantial progress, key questions remain about how proteins and lipids are selectively sorted within the Golgi for delivery to specific destinations. In this Review we highlight recent insights on the biogenesis of membrane carriers at the TGN that enable transport of macromolecules along the secretory pathway and discuss how dysfunction of the molecular machinery gives rise to Golgi-related diseases.

Indexed as

Golgi Apparatustrans-Golgi NetworkAnimalsBiological TransportHumansProtein Transport

Identifiers

PMID41214333
PMCPMC13208668

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.