Evidence map›Paper›PMID 41214329›Full record

ArticleHypertension research : official journal of the Japanese Society of Hypertension2026

Visit-to-visit blood pressure variability and dementia risk after considering antihypertensive treatment: real-world data from the Japanese National Health Insurance.

Michihiro Satoh, Hiroki Nobayashi, Shingo Nakayama, Yutaro Iwabe, Takahito Yagihashi, Seiya Izumi, Takahisa Murakami, Yuya Suzuki, Maya Toyama, Tomoko Muroya and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Blood pressure variability will start cognitive impairment.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Michihiro SatohDivision of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan. satoh.mchr@tohoku-mpu.ac.jp.
Hiroki NobayashiDivision of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Shingo NakayamaDivision of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Yutaro IwabeDivision of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Takahito YagihashiDivision of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Seiya IzumiDivision of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Takahisa MurakamiDivision of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Yuya SuzukiDivision of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Maya ToyamaDivision of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Tomoko MuroyaDivision of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Takayoshi OhkuboDepartment of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan.
Hirohito MetokiDivision of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This retrospective cohort study evaluated the association between visit-to-visit blood pressure (BP) variability and dementia risk, considering antihypertensive drug classes and medication adherence using Japanese National Health Insurance data (2015-2023) of 301,448 participants (age: 66.6 years, male: 38.6%). Visit-to-visit systolic BP (SBP) variability was assessed using the coefficient of variation (CV) from five annual health check-ups. The outcome was antidementia drug initiation as a proxy for dementia diagnosis and was analyzed using Fine-Gray models, with death as the competing outcome. For participants untreated/treated with antihypertensive medication, 366/298 initiated antidementia drugs during 2.20 ± 1.19/2.11 ± 1.19 years of follow-up, respectively. The highest SBP-CV sextile was associated with dementia risk regardless of treatment status: hazard ratio of the 6

Indexed as

Antihypertensive AgentsBlood PressureDementiaHypertensionAgedAged, 80 and overEast Asian PeopleFemaleHumansJapanMaleMiddle AgedNational Health ProgramsRetrospective StudiesRisk FactorsAntihypertensive AgentsAntihypertensive treatmentBlood pressure variabilityDementiaDigital hypertensionEpidemiology

Identifiers

PMID41214329
PMCPMC12823422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.