Evidence map›Paper›PMID 41214317›Full record

ArticleBiochemical genetics2026

Identification of the Dynamic Expression Patterns of Immune Genes in the Peripheral Blood of Acute Ischemic Stroke Patients.

Jingnan Jin, Lifang Li, Danyang Li, Xia Wang, Ni He, Liting Tian, Biying Chen, Xiaoju Li, Lanxin Zhang, Zihong Chen and 2 more

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Article in Biochemical genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Jingnan Jin *Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
Lifang Li *Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
Danyang LiDepartment of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
Xia WangDepartment of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
Ni HeDepartment of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
Liting TianDepartment of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
Biying ChenDepartment of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
Xiaoju LiDepartment of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
Lanxin ZhangDepartment of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
Zihong ChenDepartment of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
Lukuan QiaoDepartment of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
Jianjian WangDepartment of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China. wangjian_427@163.com.

Funding

Heilongjiang Chunyan Youth Science and Technology Talent team project CYQN24009Heilongjiang Provincial Natural Science Foundation YQ2021H012National Natural Science Foundation of China 82071407
6 · The paper itself

Abstract

Stroke is the second primary cause of death in the world and a main cause of disability, with ischemic stroke accounting for 80% of stroke cases. Under normal physiological conditions, there is a relative balance between the proinflammatory response and the anti-inflammatory response in brain tissue. Once ischemic stroke occurs, the balance is disrupted, and subsequent immune dysfunction occurs. However, the dynamic gene expression patterns underlying the immune-related mechanisms of acute ischemic stroke (AIS) are still not fully understood. In this study, through protein‒protein interaction network construction, random forest algorithm and immune cell subtype distribution evaluation, the 7 hub immune genes, namely, C5AR1, CD79B, TLR4, FLT3LG, IGF2R, NCR3 and PAK2, were identified. The peripheral blood of 60 AIS patients and 20 healthy controls was collected and grouped according to onset time and blood collection time. qRT‒PCR was used to measure the expression levels of hub immune genes in the peripheral blood mononuclear cells (PBMCs) of the AIS groups and control group. The results indicated that the hub immune genes were associated the onset and development of AIS. According to Pearson correlation analysis, the hub immune genes may be correlated with the dynamic immune response after AIS to some extent. In summary, our study identified 7 hub immune genes and verified the correlations between the 7 hub immune genes and the dynamic immune response after AIS. Furthermore, these genes may be novel candidate biomarkers or therapeutic targets in AIS.

Indexed as

Brain IschemiaGene Expression RegulationIschemic StrokeLeukocytes, MononuclearCase-Control StudiesFemaleGene Expression ProfilingHumansMaleProtein Interaction MapsAcute ischemic strokeBiomarkerDynamic expression patternsImmune genesPeripheral blood

Identifiers

PMID41214317

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