Evidence map›Paper›PMID 41214240›Full record

ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2026

In vivo evolution of resistance to novel β-lactam/β-lactamase inhibitor combinations through overproduction of the horizontally acquired extended-spectrum AmpC β-lactamase FOX-14 and porin disruption in Serratia marcescens.

Salud Rodríguez-Pallares, Lucía González-Pinto, María Tarriño-León, Pablo Aja-Macaya, Lucía Sánchez-Peña, Miriam Moscoso, Gloria Pérez-Rodríguez, Tania Blanco-Martín, Alejandro Beceiro, Germán Bou and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Emergence of KPC-producingAntimicrobial agents and chemotherapy · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Salud Rodríguez-PallaresServicio de Microbiología Clínica and Instituto de Investigación Biomédica A Coruña (INIBIC), Complexo Hospitalario Universitario A Coruña, Avenida As Xubias S/N, 3º Planta, A Coruña, 15006, Spain.
Lucía González-PintoServicio de Microbiología Clínica and Instituto de Investigación Biomédica A Coruña (INIBIC), Complexo Hospitalario Universitario A Coruña, Avenida As Xubias S/N, 3º Planta, A Coruña, 15006, Spain.
María Tarriño-LeónServicio de Microbiología Clínica, Hospital Universitario Virgen de las Nieves, Granada, Spain.
Pablo Aja-MacayaServicio de Microbiología Clínica and Instituto de Investigación Biomédica A Coruña (INIBIC), Complexo Hospitalario Universitario A Coruña, Avenida As Xubias S/N, 3º Planta, A Coruña, 15006, Spain.
Lucía Sánchez-PeñaServicio de Microbiología Clínica and Instituto de Investigación Biomédica A Coruña (INIBIC), Complexo Hospitalario Universitario A Coruña, Avenida As Xubias S/N, 3º Planta, A Coruña, 15006, Spain.
Miriam MoscosoServicio de Microbiología Clínica and Instituto de Investigación Biomédica A Coruña (INIBIC), Complexo Hospitalario Universitario A Coruña, Avenida As Xubias S/N, 3º Planta, A Coruña, 15006, Spain.
Gloria Pérez-RodríguezServicio de Microbiología Clínica and Instituto de Investigación Biomédica A Coruña (INIBIC), Complexo Hospitalario Universitario A Coruña, Avenida As Xubias S/N, 3º Planta, A Coruña, 15006, Spain.
Tania Blanco-MartínServicio de Microbiología Clínica and Instituto de Investigación Biomédica A Coruña (INIBIC), Complexo Hospitalario Universitario A Coruña, Avenida As Xubias S/N, 3º Planta, A Coruña, 15006, Spain.
Alejandro BeceiroServicio de Microbiología Clínica and Instituto de Investigación Biomédica A Coruña (INIBIC), Complexo Hospitalario Universitario A Coruña, Avenida As Xubias S/N, 3º Planta, A Coruña, 15006, Spain.
Germán BouServicio de Microbiología Clínica and Instituto de Investigación Biomédica A Coruña (INIBIC), Complexo Hospitalario Universitario A Coruña, Avenida As Xubias S/N, 3º Planta, A Coruña, 15006, Spain.
Jorge Arca-SuárezServicio de Microbiología Clínica and Instituto de Investigación Biomédica A Coruña (INIBIC), Complexo Hospitalario Universitario A Coruña, Avenida As Xubias S/N, 3º Planta, A Coruña, 15006, Spain. jorge.arca.suarez@sergas.es.

Funding

Axencia Galega de Innovación IN607A 2024/09Axencia Galega de Innovación IN607D 2021/12Axencia Galega de Innovación IN607D 2024/008Centro de Investigación Biotecnológica en Red de Enfermedades Infecciosas CB21/13/00055Fundación Publica Galega de investigación Biomédica (INIBIC) and Xunta de Galicia IN606A 2024/022Instituto de Salud Carlos III CM23/00095Instituto de Salud Carlos III CM23/00104Instituto de Salud Carlos III FI23/00074Instituto de Salud Carlos III JR21/00026Instituto de Salud Carlos III PI22/01212Instituto de Salud Carlos III PI23/00851Instituto de Salud Carlos III PI24/00920
6 · The paper itself

Abstract

We investigated the genetic and biochemical determinants that reduce the activity of several β-lactam/β-lactamase inhibitor combinations against Serratia marcescens clinical isolates after carbapenem exposure. We analyzed paired clinical S. marcescens isolates recovered before and after treatment of a prolonged infection with ertapenem. We tested the susceptibility of the isolates to ceftazidime/avibactam, aztreonam/avibactam, imipenem/relebactam and meropenem/vaborbactam. Mechanisms of resistance were investigated using whole-genome sequencing and RNA expression analysis. The bla

Indexed as

Anti-Bacterial AgentsBacterial Proteinsbeta-Lactamase Inhibitorsbeta-Lactamasesbeta-LactamsPorinsSerratia marcescensHumansMicrobial Sensitivity TestsSerratia InfectionsWhole Genome SequencingAmpC beta-lactamasesAnti-Bacterial AgentsBacterial Proteinsbeta-Lactamase Inhibitorsbeta-Lactamasesbeta-LactamsPorins

Identifiers

PMID41214240

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.