Evidence map›Paper›PMID 41214212›Full record

ArticleNature aging2025

Multilingualism protects against accelerated aging in cross-sectional and longitudinal analyses of 27 European countries.

Lucia Amoruso, Hernan Hernandez, Hernando Santamaria-Garcia, Sebastian Moguilner, Agustina Legaz, Pavel Prado, Jhosmary Cuadros, Liset Gonzalez, Raul Gonzalez-Gomez, Joaquín Migeot and 10 more

Abstract read
In one paragraph

Article in Nature aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Trial
  2. Article
  3. Does Multilingualism Shape Aging Equally Across Populations?Journal of immigrant and minority health · 2026
    Article
  4. The include network: Advancing cross-linguistic equity in brain health research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  5. Article
  6. Article
  7. Scientific knowledge about dementia: From the Global South to the world.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  8. Review
  9. Expotype-phenotype resilience and multimodal aging clocks.Clinical and translational medicine · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Lucia Amoruso *Basque Center on Cognition, Brain and Language (BCBL), San Sebastian, Spain.
Hernan Hernandez *Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Hernando Santamaria-GarciaPontificia Universidad Javeriana (PhD Program in Neuroscience) Bogotá, San Ignacio, Colombia.
Sebastian MoguilnerCognitive Neuroscience Center (CNC), Universidad de San Andres, Buenos Aires, Argentina.
Agustina LegazCognitive Neuroscience Center (CNC), Universidad de San Andres, Buenos Aires, Argentina.
Pavel PradoEscuela de Fonoaudiología, Facultad de Odontología y Ciencias de la Rehabilitación, Universidad San Sebastián, Santiago de Chile, Chile.
Jhosmary CuadrosLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Liset GonzalezFacultad de Ingeniería, Universidad de Concepción, Concepción, Chile.
Raul Gonzalez-GomezLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile.ORCID http://orcid.org/0000-0003-2341-011X
Joaquín MigeotLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Carlos Coronel-OliverosLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Josephine CruzatLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile.ORCID http://orcid.org/0000-0002-3252-8657
Manuel CarreirasCognitive Neuroscience Center (CNC), Universidad de San Andres, Buenos Aires, Argentina.
Vicente MedelLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Marcelo Adrián MaitoCognitive Neuroscience Center (CNC), Universidad de San Andres, Buenos Aires, Argentina.
Claudia Duran-AniotzLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile.ORCID http://orcid.org/0000-0003-2503-8366
Enzo TagliazucchiLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Sandra BaezGlobal Brain Health Institute (GBHI), University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-0875-1709
Adolfo M GarcíaCognitive Neuroscience Center (CNC), Universidad de San Andres, Buenos Aires, Argentina.ORCID http://orcid.org/0000-0002-6936-0114
Agustin IbanezLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile. agustin.ibanez@gbhi.org.

Funding

An automated machine learning approach to language changes in Alzheimer’s disease and frontotemporal dementia across Latino and English-speaking populationsR01AG075775 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI, Adolfo Martin Garcia · 2023 to 2026
$7.2M
US-South American Initiative for Genetic-Neural-Behavioral Interactions in Human Neurodegenerative ResearchR01AG057234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Claudia Duran-Aniotz, Agustin M. Ibanez · 2019 to 2026
$6.1M
NIA NIH HHS R01 AG057234NIA NIH HHS R01 AG075775
6 · The paper itself

Abstract

Aging trajectories are influenced by modifiable risk factors, and prior evidence has hinted that multilingualism may have protective potential. However, reliance on suboptimal health markers, small samples, inadequate confounder control and a focus on clinical cohorts led to mixed findings and limited applicability to healthy populations. Here, we developed biobehavioral age gaps, quantifying delayed or accelerated aging in 86,149 participants across 27 European countries. National surveys provided individual-level positive (functional ability, education, cognition) and adverse (cardiometabolic conditions, female sex, sensory impairments) factors, while country-level multilingualism served as an aggregate exposure. Biobehavioral factors predicted age (R

Indexed as

AgingAging, PrematureMultilingualismAdultAgedAged, 80 and overCross-Sectional StudiesEuropeFemaleHumansLongitudinal StudiesMaleMiddle AgedProtective FactorsRisk Factors

Identifiers

PMID41214212
PMCPMC13094028

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.