Evidence map›Paper›PMID 41214210›Full record

Articlenpj antimicrobials and resistance2025

Next generation ESKAPE-E superbugs: identifying transmissible locus of stress tolerance and antibiotic resistance in pandemic bacterial lineages.

Dmitriy Li, Veronica M Jarocki, Ethan R Wyrsch, Max L Cummins, Steven P Djordjevic

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in npj antimicrobials and resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Genomic Surveillance of ESBL-ProducingPathogens (Basel, Switzerland) · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dmitriy Li *Australian Institute for Microbiology and Infection, University of Technology Sydney, Ultimo, NSW, Australia.
Veronica M Jarocki *Australian Institute for Microbiology and Infection, University of Technology Sydney, Ultimo, NSW, Australia.
Ethan R WyrschAustralian Institute for Microbiology and Infection, University of Technology Sydney, Ultimo, NSW, Australia.
Max L CumminsAustralian Institute for Microbiology and Infection, University of Technology Sydney, Ultimo, NSW, Australia.
Steven P DjordjevicAustralian Institute for Microbiology and Infection, University of Technology Sydney, Ultimo, NSW, Australia. steven.djordjevic@uts.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transmissible locus of stress tolerance (tLST) confers enhanced resilience to stressors, including chlorine-based disinfectants and heat. A systematic examination of 48,183 complete bacterial genomes representing 7,190 unique species identified tLST, including six novel variants, in 2,128 genomes spanning 46 bacterial species across 10 families. Among the analysed sequences, tLST was most common in ESKAPE-E bacteria, including highly drug-resistant pandemic lineages of Pseudomonas aeruginosa ST111 and Klebsiella pneumoniae ST20. The tLST1_AW1.7 variant was predominantly associated with F plasmids and was the most common variant in Enterobacter and Klebsiella, whereas tLST1 was near exclusive to E. coli, and tLST3a was dominant in Pseudomonas. This comprehensive mapping of tLST distribution highlights its potential significance in bacterial adaptation and persistence across diverse ecological and anthropogenically impacted niches, and has implications for infection control and eradication, waste and drinking water management, food animal and fresh produce production, and food safety.

Identifiers

PMID41214210
PMCPMC12603250

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.