Evidence map›Paper›PMID 41214177›Full record

ArticleNature neuroscience2025

Subsecond dopamine fluctuations do not specify the vigor of ongoing actions.

Haixin Liu, Riccardo Melani, Marta Maltese, James Taniguchi, Akhila Sankaramanchi, Ruoheng Zeng, Jenna R Martin, Nicolas X Tritsch

Abstract read
In one paragraph

Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Calbindin stratifies midbrain dopaminergic neurons governing distinct aspects of locomotion.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. The Cellular and Synaptic Actions of Dopamine During Behavior.bioRxiv : the preprint server for biology · 2026
    Article
  3. The Synaptic Vesicle Priming Protein Munc13 Mediates Evoked Somatodendritic Dopamine Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Striatal Dopamine Actions and Movement: Inferences from Parkinson Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  8. Striatal Dopamine Contributions to Skilled Motor Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Haixin Liu *Neuroscience Institute, New York University Grossman School of Medicine and Fresco Institute for Parkinson's and Movement Disorders, New York University Langone Health, New York, NY, USA.ORCID http://orcid.org/0000-0003-3217-856X
Riccardo Melani *Neuroscience Institute, New York University Grossman School of Medicine and Fresco Institute for Parkinson's and Movement Disorders, New York University Langone Health, New York, NY, USA.
Marta MalteseNeuroscience Institute, New York University Grossman School of Medicine and Fresco Institute for Parkinson's and Movement Disorders, New York University Langone Health, New York, NY, USA.
James TaniguchiNeuroscience Institute, New York University Grossman School of Medicine and Fresco Institute for Parkinson's and Movement Disorders, New York University Langone Health, New York, NY, USA.
Akhila SankaramanchiNeuroscience Institute, New York University Grossman School of Medicine and Fresco Institute for Parkinson's and Movement Disorders, New York University Langone Health, New York, NY, USA.ORCID http://orcid.org/0000-0002-1182-9573
Ruoheng ZengNeuroscience Institute, New York University Grossman School of Medicine and Fresco Institute for Parkinson's and Movement Disorders, New York University Langone Health, New York, NY, USA.
Jenna R MartinNeuroscience Institute, New York University Grossman School of Medicine and Fresco Institute for Parkinson's and Movement Disorders, New York University Langone Health, New York, NY, USA.
Nicolas X TritschNeuroscience Institute, New York University Grossman School of Medicine and Fresco Institute for Parkinson's and Movement Disorders, New York University Langone Health, New York, NY, USA. nicolas.tritsch@mcgill.ca.ORCID http://orcid.org/0000-0003-3181-7681

Funding

Dissecting the Synaptic and Cellular Actions of Dopamine in Vivo - Diversity SupplementR01MH130658 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Tanya Sippy · 2022 to 2026
$3.5M
A novel framework for the functional dissection of motor systemsDP2NS105553 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TRITSCH, NICOLAS XAVIER · 2017 to 2017
$2.5M
Circuit Mechanisms of Bradykinesia in Mouse Models of Parkinson’s DiseaseR21NS133640 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KANG, UN JUNG, TRITSCH, NICOLAS XAVIER · 2024 to 2025
$466k
Canada First Research Excellence Fund (Fonds d'excellence en recherche Apogée Canada) HBHLFonds de Recherche du Québec - Santé (Fonds de la recherche en sante du Quebec) 365987NIMH NIH HHS R01 MH130658NINDS NIH HHS DP2 NS105553NINDS NIH HHS R21 NS133640U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH130658U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R21NS133640U.S. Department of Health & Human Services | NIH | NIH Office of the Director (OD) DP2NS105553
6 · The paper itself

Abstract

Dopamine (DA) is essential for the production of vigorous actions, but how DA modifies the gain of motor commands remains unclear. Here we show that subsecond DA transients in the striatum of mice are neither required nor sufficient for specifying the vigor of ongoing forelimb movements. Our findings have important implications for our understanding of how DA contributes to motor control under physiological conditions and in Parkinson's disease.

Indexed as

Corpus StriatumDopamineMotor ActivityAnimalsForelimbMaleMiceMice, Inbred C57BLMice, TransgenicMovementDopamine

Identifiers

PMID41214177
PMCPMC12672363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.