Evidence map›Paper›PMID 41214106›Full record

ArticleScientific reports2025

CLEC12A signaling represses protective immune responses and contributes to hippocampal pathology in neurotropic picornavirus infection.

M K Ameen, M Stoff, S Pavasutthipaisit, T Ebbecke, M Ciurkiewicz, T Störk, J Ruland, B Lepenies, A Beineke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

M K Ameen *Department of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany.
M Stoff *Department of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany.
S PavasutthipaisitDepartment of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany.
T EbbeckeCenter for Systems Neuroscience, Hannover, Germany.
M CiurkiewiczDepartment of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany.
T StörkDepartment of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany.
J RulandInstitute of Clinical Chemistry and Pathobiochemistry, School of Medicine, Technical University of Munich, 80333, Munich, Germany.
B LepeniesCenter for Systems Neuroscience, Hannover, Germany.
A BeinekeDepartment of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany. andreas.beineke@tiho-hannover.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurotropic viruses infect the central nervous system (CNS) and can cause severe neurological disorders. Theiler's murine encephalomyelitis virus (TMEV) infection in C57BL/6 mice serves as a model for virus-induced encephalitis and hippocampal damage. C-type lectin domain family 12 member A (CLEC12A) is an inhibitory receptor, which modulates immune responses during inflammatory processes. However, the role of CLEC12A during neurotropic virus infections remains unclear. In this study, CLEC12A-deficient (CLEC12A

Indexed as

Cardiovirus InfectionsHippocampusLectins, C-TypeReceptors, MitogenSignal TransductionTheilovirusAnimalsCytokinesMiceMice, Inbred C57BLMice, KnockoutCytokinesLectins, C-TypeReceptors, MitogenAntiviral immunityCLEC12AC-type lectin receptorHippocampal pathologyNeuroinflammationTMEV

Identifiers

PMID41214106
PMCPMC12603091

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.