ArticleScientific reports2025
Establishing a new periodontitis-like intrabony maxillary defect in rats for investigation on bone regeneration.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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8 authors.
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Abstract
The high incidence rate of periodontal bone defects and the unique regeneration characteristics of periodontal bone require a specially designed animal jawbone defect model to evaluate the appropriate periodontal bone regeneration procedure. The aim of the present investigation was to develop a reproducible, quantifiability and easy to implement periodontitis-like intrabony maxillary defect model in rats that allows investigation on bone regeneration. Ten upper jaws of rats were analyzed by micro-CT (µCT) imaging according to the bone dimensions for an appropriate position of a three-walled bone defect. A total of 30 intrabony defects measuring 1 × 1 × 1 mm were created using a split-mouth model on the palatal side of the maxillary first molar using ultrasonic surgery. 6 bone defects served as control. 20 bone defects were filled with alloplastic and xenogeneic particulate bone graft, and µCT scans were performed to verify bone regeneration of the periodontitis-like three-walled bone defect after 12 weeks. After 12 weeks, the µCT examinations showed sufficient bone regeneration of the artificially created periodontitis-typical defects. The µCT images revealed no morphological differences between xenogeneic and alloplastic bone substitute material. No restrictions for the animals, dehiscences or wound healing disorders were evident during the entire study period. The presented minimally invasive rat model with bilateral periodontitis-typical intrabony defects palatal to the first upper molar represents a favorable model for the investigation of regenerative osseous processes within a small defect.
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