ArticleScientific reports2025
Unveiling potential retinal and choroidal markers with SS-OCTA in detecting cerebral small vessel disease.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The trial behind it
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Who cites it
3 citing papers in PubMed.
- Retinal imaging for cerebrovascular risk stratification: evidence, limitations, and practical thresholds for the ophthalmologist.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
- Retinal hemodynamic and caliber biomarkers for the assessment of cerebral small vessel disease burden: insights from fundus fluorescein angiography.BMC neurology · 2026Article
- Retinal Microvascular Biomarkers Measured by Optical Coherence Tomography Angiography in Neurodegenerative and Neurovascular Disorders: A Systematic Review and Meta-Analysis.Clinical ophthalmology (Auckland, N.Z.) · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
To investigate the potential retinal and choroidal markers in identifying cerebral small vessel disease (CSVD) through Swept Source Optical Coherence Tomography Angiography (SS-OCTA). Participants were enrolled from the FRESH-CSVD study, and underwent multimodal magnetic resonance imaging (MRI) and SS-OCTA. CSVD patients were identified on multimodal MRI based on STRIVE-2 criteria. SS-OCTA parameters were captured using the VG200I device. The association between SS-OCTA parameters and CSVD imaging features was analyzed based on a least absolute shrinkage and selection operator (LASSO)-derived Logistic regression model. Subgroup analyses were conducted to explore the potentially applicable populations for identifying CSVD through SS-OCTA markers. 170 eyes (101 CSVD patients) were included. Periventricular white matter hyperintensities (PWMHs), enlarged perivascular spaces (EPVS), lacunes and CSVD burden score were all associated with OCTA parameters (all P < 0.05). In the hypertension subgroup, OCTA markers still showed associations with CSVD imaging features (all P < 0.05). SS-OCTA revealed widespread alterations of fundus blood flow in CSVD patients, especially in deep microvasculature. Relationships between SS-OCTA markers and CSVD imaging features were consistent to be detected across hypertensive populations, suggesting the potential for early CSVD screening using SS-OCTA in this population.
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