Evidence map›Paper›PMID 41213970›Full record

ArticleNature communications2025

Distinct autoreactive CD19

Van Duc Dang, Franziska Szelinski, Elodie Mohr, Tuan Anh Le, Jacob Ritter, Annika Wiedemann, Marta Ferreira-Gomes, Gabriela Maria Guerra, Pawel Durek, Frederik Heinrich and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Van Duc Dang *Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117, Berlin, Germany.ORCID http://orcid.org/0000-0002-0403-6479
Franziska Szelinski *Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117, Berlin, Germany.ORCID http://orcid.org/0000-0001-7850-5971
Elodie MohrDeutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117, Berlin, Germany.ORCID http://orcid.org/0000-0003-3406-7302
Tuan Anh LeDeutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117, Berlin, Germany.ORCID http://orcid.org/0000-0003-3239-7287
Jacob RitterDeutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117, Berlin, Germany.ORCID http://orcid.org/0000-0001-8962-1564
Annika WiedemannDeutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117, Berlin, Germany.ORCID http://orcid.org/0000-0002-0013-6579
Marta Ferreira-GomesDeutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117, Berlin, Germany.ORCID http://orcid.org/0000-0002-7171-7952
Gabriela Maria GuerraDeutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117, Berlin, Germany.
Pawel DurekDeutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117, Berlin, Germany.ORCID http://orcid.org/0000-0002-6179-0670
Frederik HeinrichDeutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117, Berlin, Germany.ORCID http://orcid.org/0000-0001-6097-5422
Hector Rincon-ArevaloDeutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117, Berlin, Germany.ORCID http://orcid.org/0000-0001-5614-7894
Ana-Luisa StefanskiDeutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117, Berlin, Germany.ORCID http://orcid.org/0000-0001-7689-6454
Eva SchrezenmeierDeutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117, Berlin, Germany.
Van T HoangVinmec Research Institute of Stem Cell and Gene Technology, College of Health Sciences, VinUniversity, Vinhomes Ocean Park, Hanoi, Vietnam.
Hong-Nhung DaoVinmec Research Institute of Stem Cell and Gene Technology, College of Health Sciences, VinUniversity, Vinhomes Ocean Park, Hanoi, Vietnam.
Soeren OcvirkIntestinal Microbiology Research Group, Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Qingyu ChengDeutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117, Berlin, Germany.
Falk HiepeDeutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117, Berlin, Germany.ORCID http://orcid.org/0000-0003-3584-5292
Christian HipflCentre for Musculoskeletal Surgery, Department of Orthopedics, Charité Universitätsmedizin Berlin, Berlin, Germany.
Sebastian HardtCentre for Musculoskeletal Surgery, Department of Orthopedics, Charité Universitätsmedizin Berlin, Berlin, Germany.
Max LöhningDeutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117, Berlin, Germany.ORCID http://orcid.org/0000-0001-6382-7281
Liem Thanh NguyenVinmec Research Institute of Stem Cell and Gene Technology, College of Health Sciences, VinUniversity, Vinhomes Ocean Park, Hanoi, Vietnam.
Mir-Farzin MashreghiDeutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117, Berlin, Germany.ORCID http://orcid.org/0000-0002-8015-6907
Simon FillatreauInstitut Necker Enfants Malades, INSERM U1151-CNRS UMR 8253, Paris, France.ORCID http://orcid.org/0000-0002-7730-9917
Thomas DörnerDeutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117, Berlin, Germany.ORCID http://orcid.org/0000-0002-6478-7725
Andreia C LinoDeutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117, Berlin, Germany. andreialino79@gmail.com.ORCID http://orcid.org/0000-0002-3791-8232

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plasma cells (PC) participate in the pathogenesis of systemic lupus erythematosus (SLE) through sustained autoantibody and inflammatory cytokine secretion. Current PC-depleting therapies risk eliminating protective long-lived PCs, highlighting the need to identify pathogenic subsets for selective targeting. Here, using single-cell RNA sequencing, B cell receptor repertoire analysis, and genetic models, we identify disease- and organ-specific PCs in lupus-prone mice. We find a substantial expansion of autoreactive CD19

Indexed as

Antigens, CD19Lupus Erythematosus, SystemicPlasma CellsAnimalsAutoantibodiesDisease Models, AnimalFemaleHumansMaleMiceMice, Inbred C57BLReceptors, CXCR3Single-Cell AnalysisAntigens, CD19AutoantibodiesReceptors, CXCR3

Identifiers

PMID41213970
PMCPMC12603280

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.