ArticleBMJ open respiratory research2025
Ferroptosis-associated genes as candidate biomarkers for the identification of patients with severe influenza necessitating mechanical ventilation.
Article in BMJ open respiratory research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Abstract
backgroundFerroptotic cell death is a highly regulated process characterised by the iron-dependent accumulation of lipid peroxides on cell membranes. However, the role of ferroptosis-related genes (FRGs) in severe influenza is not well characterised.
methodsInfluenza-related gene expression data and FRG lists were, respectively, downloaded from the gene expression omnibus and ferroptosis database. Differentially expressed FRGs (DE-FRGs) were then identified by comparing samples from patients with and without severe influenza, respectively, defined by patients who did and did not require mechanical ventilation. Enrichment analyses of these DE-FRGs were performed, and hub genes were subsequently identified, enabling the establishment of hub gene-drug interaction and competing endogenous RNA (ceRNA) networks.
resultsIn total, these analyses revealed 171 DE-FRGs from patients with and without severe influenza. Least absolute shrinkage and selection operator and support vector machine-recursive feature elimination algorithms were used to identify eight hub genes from this dataset (
conclusionThe eight hub FRGs established in this study may play an important role in shaping the pathogenesis of severe influenza in individuals and may offer value as biomarkers that can guide the personalised prevention and treatment of this severe form of disease.
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