Evidence map›Paper›PMID 41213683›Full record

ArticleBMJ open2025

Protocol for an economic evaluation alongside the Re-Evaluating the Inhibition of Stress Erosions (E-REVISE) trial.

Brittany Humphries, Nicole Zytaruk, Diane Heels-Ansdell, Vincent Lau, Bram Rochwerg, Robert Fowler, Yifan Yao, Deborah J Cook, Feng Xie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Brittany HumphriesHealth Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0001-9364-5788
Nicole ZytarukHealth Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
Diane Heels-AnsdellHealth Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0003-4362-801X
Vincent LauCritical Care Medicine, University of Alberta, Edmonton, Alberta, Canada.ORCID http://orcid.org/0000-0002-9939-7348
Bram RochwergHealth Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
Robert FowlerInterdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada.
Yifan YaoHealth Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
Deborah J CookHealth Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0002-4087-543X
Feng XieHealth Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada fengxie@mcmaster.ca.ORCID http://orcid.org/0000-0003-3454-6266

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionEconomic evaluations in healthcare can guide practice and inform policy. The objective of this paper is to present the protocol for a health economic evaluation comparing the cost-effectiveness of prophylactic treatment using pantoprazole 40 mg daily compared with no pantoprazole to prevent upper gastrointestinal (GI) bleed among invasively ventilated patients. METHODS AND ANALYSIS: This is an economic evaluation conducted alongside the ETHICS AND DISSEMINATION: The trial was approved by each participating institution; this economic evaluation was approved by the Hamilton Integrated Research Ethics Board. Given widespread daily use of proton pump inhibitors for critically ill patients, the results of this economic evaluation will be of high relevance to patients, family members, physicians, pharmacists, policymakers and guideline developers. Integrated knowledge translation will involve periodic progress reports to collaborators. End-of-study knowledge translation will include rounds, videoconferences, abstracts and slide-decks for intensive care unit quality councils and healthcare organisations, and open-access publications. Patient and family partners will co-create lay language summaries for traditional and social media to help inform all interest groups.

Indexed as

Anti-Ulcer AgentsGastrointestinal HemorrhagePantoprazoleProton Pump InhibitorsRespiration, ArtificialClinical Trials, Phase III as TopicCost-Benefit AnalysisHumansAnti-Ulcer AgentsPantoprazoleProton Pump InhibitorsGASTROENTEROLOGYHEALTH ECONOMICSINTENSIVE & CRITICAL CARE

Identifiers

PMID41213683
PMCPMC12658520

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.