ReviewBiological psychiatry2026
A Comparison of Positive and Negative Allosteric Modulators of α5-Containing GABA
Review in Biological psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Development of Novel Pegylated Imidazobenzodiazepines Targeting α5 GABAA Receptors for Anxiety: A Comparative Prodrug and Metabolite Study.ACS chemical neuroscience · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Major depressive disorder (MDD) is a common psychiatric disease that significantly impairs quality of life and productivity. Standard monoamine-based therapies are marred by poor efficacy. Disruptions in the balance of glutamate- and GABA (gamma-aminobutyric acid)-mediated neurotransmission in regions associated with reward, emotion, and cognitive processing likely underpin the neurobiology of depression. Subunit-preferring compounds may positively (GABA-positive allosteric modulators [PAMs]) or negatively (GABA-negative allosteric modulators [NAMs]) modulate the ability of GABA to activate inhibitory GABA
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.