ArticleAging and disease2025
A Signature of Senescence Based on An Analysis of Selected Markers in Primary Vascular Smooth Muscle Cells Cultured In Vitro and Derived from Atherosclerotic Plaque.
Article in Aging and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cellular senescence is a state of stable growth arrest that is accompanied by a characteristic phenotype. The senescent phenotype is dynamic and heterogeneous, and it depends on both the type of cell and the factors that trigger senescence. There is no single biomarker that is shared by all senescent cell types. Therefore, our studies aimed to define a set of biomarkers that can discriminate among proliferating, senescent and temporally growth-arrested (quiescent) cells. We analysed vascular smooth muscle cells (VSMCs) derived from healthy aortae that underwent senescence in vitro but also VSMCs isolated from human atherosclerotic plaques that underwent senescence in vivo. Our results demonstrate that changes in the levels of nuclear proteins (Lamin B1, HMGB1, PARP1) are the most consistent, stable and widespread in cells senescing in vitro while changes in the levels of signalling proteins implicated in senescence (p53, p21
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