Evidence map›Paper›PMID 41213085›Full record

ArticleAging and disease2025

Lamotrigine Restores Impairments in Theta Rhythms and LTP as Early Biomarkers of Aβ

Maciej Studzian, Bartosz Bobula, M Bruce MacIver, Renata Bocian, Anna Kobrzycka, Bartosz Caban, Tomasz Kowalczyk, Jacek Grebowski, Sylwia Michlewska, Maciej M Jankowski and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Maciej StudzianUniversity of Lodz, Faculty of Biology and Environmental Protection, Department of Oncobiology and Epigenetics, 90-236 Lodz, Poland.
Bartosz BobulaDepartment of Physiology, Maj Institute of Pharmacology, Polish Academy of Sciences, 31-343 Krakow, Poland.
M Bruce MacIverNeuroscience Institute, School of Medicine, Stanford University, Palo Alto, CA 94305, USA.
Renata BocianUniversity of Lodz, Faculty of Biology and Environmental Protection, Department of Neurobiology, 90-236 Lodz, Poland.
Anna KobrzyckaUniversity of Lodz, Faculty of Biology and Environmental Protection, Department of Neurobiology, 90-236 Lodz, Poland.
Bartosz CabanUniversity of Lodz, Faculty of Biology and Environmental Protection, Department of Neurobiology, 90-236 Lodz, Poland.
Tomasz KowalczykUniversity of Lodz, Faculty of Biology and Environmental Protection, Department of Neurobiology, 90-236 Lodz, Poland.
Jacek GrebowskiUniversity of Lodz, Faculty of Biology and Environmental Protection, Department of Oncobiology and Epigenetics, 90-236 Lodz, Poland.
Sylwia MichlewskaUniversity of Lodz, Faculty of Biology and Environmental Protection, Laboratory of Microscopic Imaging and Specialized Biological Techniques, 90-237 Lodz, Poland.
Maciej M JankowskiGdansk University of Technology, Faculty of Electronics, Telecommunications and Informatics, Multimedia Systems Department, BioTechMed Center, 80-233 Gdansk, Poland.
Krzysztof TokarskiDepartment of Physiology, Maj Institute of Pharmacology, Polish Academy of Sciences, 31-343 Krakow, Poland.
Paulina Kazmierska-GrebowskaUniversity of Lodz, Faculty of Biology and Environmental Protection, Department of Neurobiology, 90-236 Lodz, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuronal excitation/inhibition (E/I) imbalance, epileptiform activity, and synaptic dysfunction are present in individuals diagnosed with dementia, including sporadic Alzheimer's disease (sAD), even at early stages. These abnormalities are associated with altered neuronal oscillatory activity, as seen in EEG recordings of sAD patients and transgenic rodents. Hippocampal theta oscillations are crucial for sensorimotor integration, memory consolidation, and network coordination, and depend on synaptic and ionic mechanisms, including the Ih current, mediated by hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. Lamotrigine (LTG), an HCN channel modulator, influences neuronal excitability and oscillations. Amyloid beta (Aβ) peptide, specifically Aβ

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesHippocampusLong-Term PotentiationPeptide FragmentsTheta RhythmTriazinesAnimalsBiomarkersDisease Models, AnimalLamotrigineMaleRatsAmyloid beta-Peptidesamyloid beta-protein (1-42)BiomarkersLamotriginePeptide FragmentsTriazines

Identifiers

PMID41213085
PMCPMC13653730

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.