Evidence map›Paper›PMID 41213015›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Biomolecular condensation of ERC1 recruits ATG8 and NBR1 to drive autophagosome formation for plant heat tolerance.

Ka Kit Chung, Kai Ching Law, Ziwei Zhao, Juncai Ma, Xiao-Tong Zhan, Cheuk Him Chiang, Kwan Ho Leung, Ruben Shrestha, Yixin Wu, Chaorui Li and 7 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Ka Kit Chung *School of Life Sciences, Centre for Plant Vacuole Biology and Biotechnology, Centre for Cell & Developmental Biology and State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Shatin, Hong Kong, China.ORCID 0009-0005-8589-4676
Kai Ching Law *School of Life Sciences, Centre for Plant Vacuole Biology and Biotechnology, Centre for Cell & Developmental Biology and State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Shatin, Hong Kong, China.ORCID 0009-0009-2354-0150
Ziwei Zhao *School of Life Sciences, Centre for Plant Vacuole Biology and Biotechnology, Centre for Cell & Developmental Biology and State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
Juncai MaSchool of Life Sciences, Centre for Plant Vacuole Biology and Biotechnology, Centre for Cell & Developmental Biology and State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Shatin, Hong Kong, China.ORCID 0000-0002-5693-1117
Xiao-Tong ZhanSchool of Life Sciences, Centre for Plant Vacuole Biology and Biotechnology, Centre for Cell & Developmental Biology and State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
Cheuk Him ChiangSchool of Life Sciences, Centre for Plant Vacuole Biology and Biotechnology, Centre for Cell & Developmental Biology and State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Shatin, Hong Kong, China.ORCID 0009-0004-9047-9058
Kwan Ho LeungSchool of Life Sciences, Centre for Plant Vacuole Biology and Biotechnology, Centre for Cell & Developmental Biology and State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Shatin, Hong Kong, China.ORCID 0009-0006-8299-5591
Ruben ShresthaDivision of Biosphere Sciences and Engineering, Carnegie Science, Stanford, CA 94305.
Yixin WuSchool of Life Sciences, Centre for Plant Vacuole Biology and Biotechnology, Centre for Cell & Developmental Biology and State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Shatin, Hong Kong, China.ORCID 0000-0002-2129-0831
Chaorui LiSchool of Life Sciences, Centre for Plant Vacuole Biology and Biotechnology, Centre for Cell & Developmental Biology and State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Shatin, Hong Kong, China.ORCID 0000-0001-6056-5490
Ka Ming LeeSchool of Life Sciences, Centre for Protein Science and Crystallography, State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
Lei FengGuangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Sciences, Ministry of Education Key Laboratory & Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.
Xibao LiGuangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Sciences, Ministry of Education Key Laboratory & Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.ORCID 0000-0002-6978-7660
Kam Bo WongSchool of Life Sciences, Centre for Protein Science and Crystallography, State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Shatin, Hong Kong, China.ORCID 0000-0002-6984-5373
Shou-Ling XuDivision of Biosphere Sciences and Engineering, Carnegie Science, Stanford, CA 94305.ORCID 0000-0002-6741-9506
Caiji GaoGuangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Sciences, Ministry of Education Key Laboratory & Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.ORCID 0000-0003-3958-4499
Xiaohong ZhuangSchool of Life Sciences, Centre for Plant Vacuole Biology and Biotechnology, Centre for Cell & Developmental Biology and State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Shatin, Hong Kong, China.ORCID 0000-0002-2480-8210

Funding

Nutrient regulation of Alternative splicing and transcription by O-GlcNAcylationR01GM135706 · NIGMS · CARNEGIE INSTITUTION OF WASHINGTON, D.C. · PI XU, SHOULING · 2020 to 2024
$1.8M
NIGMS NIH HHS R01 GM135706
6 · The paper itself

Abstract

Macroautophagy (hereafter autophagy) is essential for cells to respond to nutrient deficiency by delivering cytosolic contents to vacuoles for degradation via the formation of a multilayer organelle named an autophagosome. A set of autophagy-related (ATG) regulators are recruited to the phagophore assembly site for phagophore initiation, including its expansion and closure, and subsequent delivery into the vacuole. However, it remains elusive how the phagophore assembly is regulated under different stress conditions. Here, we described an uncharacterized

Indexed as

ArabidopsisArabidopsis ProteinsAutophagosomesAutophagy-Related Protein 8 FamilyThermotoleranceAutophagyCarrier ProteinsArabidopsis ProteinsATG8 protein, ArabidopsisAutophagy-Related Protein 8 FamilyCarrier ProteinsNBR1 protein, ArabidopsisATG8autophagosome formationbiomolecular condensationERC protein familyNBR1

Identifiers

PMID41213015
PMCPMC12646234

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.