Evidence map›Paper›PMID 41212832›Full record

ReviewNeonatology2026

Oxygen during Neonatal Resuscitation: Too Much versus Too Little, Does It Matter?

Deepika Sankaran, Anup C Katheria, Vishal Kapadia, Satyan Lakshminrusimha, Ola D Saugstad

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neonatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Deepika SankaranDivision of Neonatology, Department of Pediatrics, University of California Davis, Sacramento, California, USA.
Anup C KatheriaNeonatal Research Institute, Sharp Mary Birch Hospital for Women and Newborns, San Diego, California, USA.
Vishal KapadiaDivision of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern, Dallas, Texas, USA.
Satyan LakshminrusimhaDivision of Neonatology, Department of Pediatrics, University of California Davis, Sacramento, California, USA, slakshmi@health.ucdavis.edu.
Ola D SaugstadDepartment of Pediatric Research, University of Oslo, Oslo, Norway.

Funding

UC Davis Clinical and Translational Science CenterUL1TR001860 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KENYON, NICHOLAS J., LYLES, COURTNEY REES · 2016 to 2025
$47.3M
Institutional Career Development Core (KL2)KL2TR001859 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HOLMES, JAMES F. · 2016 to 2025
$10.1M
Optimal Oxygenation in Neonatal Lung InjuryR01HD072929 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Satyanarayana Lakshminrusimha · 2012 to 2026
$5.4M
OPTImal vasoPRESsor in persistent pulmonary hypertension of the newborn (OPTIPRES)K08HL181183 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Deepika Sankaran · 2025 to 2026
$330k
Neonatal Hypovolemic Cardiac Arrest: Role of Early Rapid Volume ResuscitationR03HD109443 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SANKARAN, DEEPIKA · 2023 to 2023
$160k
NCATS NIH HHS KL2 TR001859NCATS NIH HHS UL1 TR001860NHLBI NIH HHS K08 HL181183NICHD NIH HHS R01 HD072929NICHD NIH HHS R03 HD109443
6 · The paper itself

Abstract

<p>Background: Oxygen has been a key component of neonatal resuscitation for nearly two centuries. Based on clinical trials that demonstrated worse outcomes when neonatal resuscitation was initiated with 100% oxygen, there was a change in approach to using 21% oxygen at the initiation of ventilation for newborns at birth. However, for extremely preterm newborns, lower oxygen levels lead to early hypoxia and bradycardia, leading to higher rates of severe intraventricular hemorrhage and death. The balance between hyperoxia and hypoxia-related injury needs further refinement and may not be generalizable to all gestations and birth conditions. Summary: This article reviews the current evidence on oxygen use during delayed cord clamping, during resuscitation of term and preterm neonates, during chest compressions, after return of spontaneous circulation and in the post-resuscitation phase, and the impact of hyperoxia. Key Messages: Supplemental oxygen during neonatal resuscitation is actively being investigated by researchers worldwide to fill the knowledge gap to avoid hypoxia and hyperoxia while improving neonatal outcomes. Until further evidence emerges, we recommend starting resuscitation in the delivery room of very-low-birth-weight infants with an FiO

Indexed as

OxygenOxygen Inhalation TherapyResuscitationHumansHyperoxiaHypoxiaInfant, NewbornInfant, PrematureInfant, Very Low Birth WeightUmbilical Cord ClampingOxygenDelayed cord clampingHyperoxiaNeonatal ventilationOxygenPreterm newborn

Identifiers

PMID41212832
PMCPMC12640259

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.