Evidence map›Paper›PMID 41212806›Full record

ArticleDevelopmental neuroscience2025

Imbalanced Innervation of the Hypothalamic Paraventricular Nucleus by the AgRP and α-Melanocyte-Stimulating Hormone Axonal Projections in Germ-Free Mice.

Oarii Vahirua, Mouna El Mehdi, Emilie Lahaye, Aurélie Balvay, Sylvie Rabot, Sergueï O Fetissov

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Article in Developmental neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Oarii VahiruaRegulatory Peptides - Energy Metabolism and Motivated Behavior Team, Neuroendocrine, Endocrine and Germinal Differentiation and Communication Laboratory, Inserm UMR1239, University of Rouen Normandie, Rouen, France.
Mouna El MehdiRegulatory Peptides - Energy Metabolism and Motivated Behavior Team, Neuroendocrine, Endocrine and Germinal Differentiation and Communication Laboratory, Inserm UMR1239, University of Rouen Normandie, Rouen, France.
Emilie LahayeRegulatory Peptides - Energy Metabolism and Motivated Behavior Team, Neuroendocrine, Endocrine and Germinal Differentiation and Communication Laboratory, Inserm UMR1239, University of Rouen Normandie, Rouen, France.
Aurélie BalvayMicalis Institute, INRAE, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France.
Sylvie RabotMicalis Institute, INRAE, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France.
Sergueï O FetissovRegulatory Peptides - Energy Metabolism and Motivated Behavior Team, Neuroendocrine, Endocrine and Germinal Differentiation and Communication Laboratory, Inserm UMR1239, University of Rouen Normandie, Rouen, France, serguei.fetissov@univ-rouen.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInnervation of the paraventricular nucleus of the hypothalamus (PVN) by the orexigenic agouti-related protein (AgRP) and anorexigenic α-melanocyte-stimulating hormone (α-MSH) neurons of the arcuate nucleus (ARC) is a key element in the appetite-regulating neuronal circuitry whose development is influenced by circulating metabolic signals. In the present work, we studied if PVN innervation by the AgRP and α-MSH fibers is influenced by gut microbiota.

methodsTo this aim, we compared, using immunohistochemistry, the innervation of PVN by AgRP and α-MSH fibers between germ-free and specific pathogen-free 7-week-old female mice.

resultsWe found that germ-free mice display an increased innervation of the PVN by both AgRP and α-MSH fibers, but also that the increase in AgRP fiber density was about twice as pronounced as that of α-MSH.

conclusionThese data reveal that gut microbiota plays a modulatory role in the development of the ARC/PVN axonal projections. An imbalance between AgRP and α-MSH innervation in germ-free mice may contribute to their metabolic and behavioral alterations.

Indexed as

AppetiteArcuate nucleusGerm-free miceGut microbiota-brain axisHypothalamusNeuropeptides

Identifiers

PMID41212806
PMCPMC12707912

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