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ArticleCerebrovascular diseases (Basel, Switzerland)2026

Relation between Cerebral Small Vessel Function at 7T MRI and Small Vessel Disease Burden in a General Aging Population.

Stanley D T Pham, Madouc B Linders, Anna M Streiber, Carmen Kuenen, Jeroen C W Siero, Nikki Dieleman, Jaco J M Zwanenburg, Julia Neitzel, Daniel Bos, Marleen de Bruijne and 2 more

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Article in Cerebrovascular diseases (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Stanley D T PhamTranslational Neuroimaging Group, Center for Image Sciences, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Madouc B LindersTranslational Neuroimaging Group, Center for Image Sciences, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Anna M StreiberDepartment of Radiology and Nuclear Medicine, EMC, Rotterdam, The Netherlands.
Carmen KuenenDepartment of Radiology and Nuclear Medicine, EMC, Rotterdam, The Netherlands.
Jeroen C W SieroTranslational Neuroimaging Group, Center for Image Sciences, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Nikki DielemanDepartment of Neurology, University Medical Center Utrecht Brain Center, Utrecht, The Netherlands.
Jaco J M ZwanenburgTranslational Neuroimaging Group, Center for Image Sciences, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Julia NeitzelDepartment of Radiology and Nuclear Medicine, EMC, Rotterdam, The Netherlands.
Daniel BosDepartment of Radiology and Nuclear Medicine, EMC, Rotterdam, The Netherlands.
Marleen de BruijneDepartment of Radiology and Nuclear Medicine, EMC, Rotterdam, The Netherlands.
Meike W VernooijDepartment of Radiology and Nuclear Medicine, EMC, Rotterdam, The Netherlands, m.vernooij@erasmusmc.nl.
Geert Jan BiesselsDepartment of Neurology, University Medical Center Utrecht Brain Center, Utrecht, The Netherlands, g.j.biessels@umcutrecht.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

<p>Introduction: There is a need for measures of early stages of cerebral small vessel diseases (cSVDs). Recently, using 7T MRI, abnormalities of small vessel function were reported in patients with clinically manifest cSVD. The question is if such abnormalities are also present in early, covert stages of cSVD. We, therefore, studied the relation between cerebral small vessel function measures on 7T MRI and the burden of covert cSVD in the general aging population.

methodsTwo hundred participants (mean age [years] ± SD: 71 ± 5, 43% women) without a history of stroke or dementia from the Rotterdam Study were included. Small vessel measures at 7T MRI, including perforating artery blood flow velocity and pulsatility and cerebrovascular reactivity (CVR) to carbon dioxide, were related to markers of cSVD burden at 1.5T MRI, including white matter hyperintensity (WMH) volume and microbleed, enlarged perivascular spaces, and lacune presence, using linear and logistic regression analyses. We also included cognitive performance as a clinical indicator of covert cSVD.

resultsAcross the population, neither perforating artery flow measures nor CVR were significantly associated with cSVD lesion burden or cognition, with small point estimates and no consistent direction of effects. Yet, within individuals, CVR was lower inside WMHs compared to normal-appearing white matter (CVR

conclusionAlthough these data confirm that vascular function is affected within WMH, we did not observe relations between small vessel function measures at 7T MRI and the burden of covert cSVD in this population-based sample. Apparently, these measures have limited sensitivity to early stages of cSVD. </p>.

Indexed as

AgingCerebral Small Vessel DiseasesCerebrovascular CirculationMagnetic Resonance ImagingAgedAged, 80 and overAge FactorsBlood Flow VelocityCognitionFemaleHumansLeukoencephalopathiesMaleMiddle AgedNetherlandsPredictive Value of TestsCovert cerebral small vessel diseasesMRIPopulation cohortSmall vessel diseaseWhite matter damage

Identifiers

PMID41212802
PMCPMC12700580

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.