ArticleCancer control : journal of the Moffitt Cancer Center
Effectiveness of Chemotherapy Plus Immunotherapy and Molecular Alterations in Advanced Biliary Tract Cancer: Real-World Evidence From a Single-Center Australian Cohort.
Article in Cancer control : journal of the Moffitt Cancer Center. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Article
- Clinical Prognostic Factors and Survival Risk Stratification for Advanced Biliary Tract Cancer Treated with Gemcitabine-Based Palliative Chemotherapy: A Real-World Retrospective Study.Life (Basel, Switzerland) · 2026Article
- Choosing the Platinum Partner in Advanced Biliary Tract Cancer: A Propensity Score-Matched Real-World Comparison of Gemcitabine Plus Carboplatin Versus Gemcitabine Plus Cisplatin.Life (Basel, Switzerland) · 2026Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
IntroductionImmune checkpoint inhibitors plus chemotherapy has become the new standard of care for advanced biliary tract cancer (BTC). However, the real-world effectiveness and safety of this approach, and its association with molecular alterations, remains uncertain.MethodsIn this single institutional retrospective cohort study, patients with advanced BTC treated with systemic chemotherapy with or without immunotherapy from July 2020 to June 2025 were included. Primary endpoint was overall survival (OS) in patients treated with first-line chemoimmunotherapy; secondary endpoints included progression-free survival (PFS), objective response rate (ORR), safety, prognostic factors, and molecular profiling.Results49 of 52 patients (94.2%) received chemoimmunotherapy. Median OS and PFS were 10.2 months and 5.4 months, respectively; the ORR was 24.5%. Poor Eastern Cooperative Oncology Group (ECOG) performance status and hypoalbuminemia were independent predictors of poor OS. Among the 52 patients, molecular profiling identified
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