Evidence map›Paper›PMID 41212587›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2025

Acute binge alcohol increases risk of arrhythmias and myocardial fibrosis in a mouse model of arrhythmogenic cardiomyopathy.

Emily A Shiel, Waleed Farra, Steven Medarev, Gallage H D N Ariyaratne, Elisa N Cannon, Jennifer L Steiner, Stephen P Chelko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Emily A ShielDepartment of Biomedical Sciences, Florida State University, Tallahassee, Florida, United States.ORCID 0009-0009-6491-4331
Waleed FarraDepartment of Biomedical Sciences, Florida State University, Tallahassee, Florida, United States.
Steven MedarevDepartment of Biomedical Sciences, Florida State University, Tallahassee, Florida, United States.ORCID 0009-0006-4675-8310
Gallage H D N AriyaratneDepartment of Biomedical Sciences, Florida State University, Tallahassee, Florida, United States.ORCID 0000-0001-6766-8329
Elisa N CannonDepartment of Biomedical Sciences, Florida State University, Tallahassee, Florida, United States.ORCID 0009-0008-9807-5831
Jennifer L SteinerDepartment of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, Florida, United States.ORCID 0000-0002-0244-4233
Stephen P ChelkoDepartment of Biomedical Sciences, Florida State University, Tallahassee, Florida, United States.ORCID 0000-0003-1675-5945

Funding

Alcohol and the skeletal muscle clockR21AA031567 · NIAAA · FLORIDA STATE UNIVERSITY · PI STEINER, JENNIFER LYNN · 2024 to 2025
$389k
Impact of Alcohol on Aging Skeletal MuscleR03AA030408 · NIAAA · FLORIDA STATE UNIVERSITY · PI STEINER, JENNIFER LYNN · 2022 to 2023
$154k
American Heart Association (AHA) 25PRE1372729Florida State University (FSU) Eesearch Foundation Award 2023-2026Florida State University (FSU) Institute of Pediatric Rare Diseases 2024-2025HHS | National Institutes of Health (NIH) R03AA030408HHS | National Institutes of Health (NIH) R21AA031567NIAAA NIH HHS R03 AA030408NIAAA NIH HHS R21 AA031567
6 · The paper itself

Abstract

Arrhythmogenic cardiomyopathy (ACM) is an inherited heart disease characterized by myocardial inflammation and fibrosis, ventricular dysfunction, and arrhythmias, and is a leading cause of sudden cardiac death in young adults. Acute binge alcohol consumption is a common behavior of young adults and is known to cause transient cardiac stress; however, its impact on ACM remains unclear. Wild-type and homozygous desmoglein-2 mutant (

Indexed as

Arrhythmias, CardiacArrhythmogenic Right Ventricular DysplasiaBinge DrinkingEthanolMyocardiumAnimalsDisease Models, AnimalFibrosisMaleMiceMice, Inbred C57BLSignal TransductionEthanolalcoholarrhythmiaarrhythmogenic cardiomyopathydesmoglein-2myocardial fibrosis

Identifiers

PMID41212587
PMCPMC12771544

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.