ArticleOdontology2026
Expression and biological functions of miR-486-5p in peri-implantitis.
Article in Odontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peri-implantitis (PI) is a prevalent complication of denture implantation, and the consequences of PI on dental implantation are irreversible. This research examined the levels and clinical significance of miR-486-5p in PI patients, while also investigating its biological role in the PI progression using a cellular model. Quantitative polymerase chain reaction (qPCR) was employed to assess the miR-486-5p levels. The diagnostic significance of miR-486-5p, along with its relationship to periodontal indicators and prognosis, was evaluated through ROC and Pearson correlation analysis. Additionally, the LPS cell injury model was established to investigate the effects of both the miR-486-5p overexpression and inhibition on the proliferation and apoptosis of hPDLFs utilizing CCK-8 and flow cytometry. Furthermore, the miR-486-5p regulation on inflammatory factors and oxidative stress levels was assessed through ELISA. The miR-486-5p levels in PI patients were elevated, demonstrating considerable diagnostic potential for this condition. miR-486-5p might serve as an important indicator for assessing the periodontal status and prognosis of PI patients. In cell models, miR-486-5p overexpression could inhibit proliferation and promote apoptosis of hPDLFs, as well as enhance the inflammatory mediators release and oxidative stress-related damage. Conversely, the inhibition of miR-486-5p expression could counteract the promoting effect of LPS on inflammatory response. miR-486-5p is a potential diagnostic biomarker of PI. The up-regulated miR-486-5p might intensify inflammatory responses and impair cellular functionality, consequently facilitating the progression of PI.
Indexed as
Identifiers
41212456What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.