Evidence map›Paper›PMID 41212452›Full record

ArticleDiscover oncology2025

Comprehensive analysis of zinc finger protein 367 as a potential pan-cancer diagnostic and prognostic biomarker and underlying biological mechanisms.

Qi Feng, Ding-Fan Guo, Ting Wang, Kun-He Zhang

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Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Qi FengDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No.17, Yongwai Zheng Street, Nanchang, Jiangxi, China.
Ding-Fan GuoDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No.17, Yongwai Zheng Street, Nanchang, Jiangxi, China.
Ting WangDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No.17, Yongwai Zheng Street, Nanchang, Jiangxi, China.
Kun-He ZhangDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No.17, Yongwai Zheng Street, Nanchang, Jiangxi, China. khzhang@ncu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveZinc finger protein 367 (ZNF367) acts as a transcription factor and has been identified as overexpressed in numerous cancers. However, the clinical significance of ZNF367 in various cancers remains fragmentary. Therefore, this study performs a comprehensive pan-cancer analysis of ZNF367 for its diagnostic and prognostic value and underlying biological mechanisms across multiple cancer types.

methodsMulti-omics data from the website databases were utilized for analyzing the pan-cancer expression landscape of ZNF367 and its potential diagnostic and prognostic significance, and validating its expression in some cancers by immunohistochemistry, followed by a series of biological analyses using online bioinformatics tools to investigate the underlying mechanisms, including the genetic and epigenetic alterations of the ZNF367 gene, interaction networks of ZNF367 with proteins and genes, associations of ZNF367 with tumor genetic heterogeneity and tumor microenvironment characteristics.

resultsZNF367 expression levels were elevated in the majority of cancers, validated its overexpression of protein in some cancers, and showed moderate to high diagnostic performance in 26 cancer types. Overexpression of ZNF367 was connected with unfavorable prognostic outcomes across several malignancies and acted as an independent risk factor using multivariate Cox regression analysis in some tumors. Common genetic alterations of ZNF367 included mutations and amplifications. KEGG functional analysis uncovered that ZNF367-associated genes participated in multiple cancer-related pathways. Significant correlations were observed between ZNF367 and tumor genetic heterogeneity, DNA methylation, immune infiltration and ZNF367-related genes in most cancers.

conclusionZNF367 may emerge as a valuable pan-cancer diagnostic and prognostic biomarker supported by biological evidence.

Indexed as

Biological mechanismDiagnosisPan-cancerPrognosisZNF367

Identifiers

PMID41212452
PMCPMC12602748

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