Evidence map›Paper›PMID 41212427›Full record

ReviewCurrent obesity reports2025

Climate Change, Air Pollution and the Global Obesity Syndemic: a Review of Current Evidence.

Natalia G Vallianou, Dimitris C Kounatidis, Eleni V Geladari, Angelos Evangelopoulos, Vasileios Kaldis, Theodora Stratigou, Apostolos A Evangelopoulos, Irene Karampela, Maria Dalamaga

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current obesity reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Natalia G VallianouFirst Department of Internal Medicine, Sismanogleio General Hospital, Athens, 15126, Greece. natalia.vallianou@gmail.com.
Dimitris C KounatidisFirst Propaedeutic Department of Internal Medicine, Diabetes Center, Medical School, Laiko General Hospital, National and Kapodistrian University of Athens, Athens, 11527, Greece.
Eleni V GeladariThird Department of Internal Medicine, Evangelismos General Hospital, Athens, 10676, Greece.
Angelos EvangelopoulosRoche Diagnostics Hellas S.A. 15125, Athens, Greece.
Vasileios KaldisEmergency Department, Sismanogleio General Hospital, Athens, 15126, Greece.
Theodora StratigouDiabetes and Endocrinology Department, Evangelismos General Hospital, Athens, 10676, Greece.
Apostolos A EvangelopoulosMedical School, National and Kapodistrian University of Athens, Athens, 11527, Greece.
Irene KarampelaSecond Department of Critical Care, Attikon General University Hospital, National and Kapodistrian University of Athens, Athens, 12462, Greece.
Maria DalamagaDepartment of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, 11527, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewClimate change and obesity are two converging global crises with complex and interrelated pathways. This review aims to synthesize recent evidence linking climate-related exposures, including rising ambient temperatures, air pollution, and urbanization to the pathogenesis of obesity. It also explores how obesity itself increases vulnerability to heat injury and environmental stress, highlighting the bidirectional nature of this syndemic. RECENT

findingsEpidemiologic evidence has supported associations between air pollution and increased body mass index, central adiposity, and metabolic dysfunction across the lifespan. Mechanistic research implicates impaired thermogenesis, chronic inflammation and oxidative stress, endocrine disruption, hypothalamic inflammation, and microbiome dysbiosis as key pathways linking environmental exposures to adiposity. Obesity further amplifies the physiological burden of climate-related stressors, such as heatwaves, due to reduced heat dissipation and altered hormonal responses. Anti-obesity medications may exacerbate heat-related risks via dehydration and gastrointestinal side effects. Urban greenness appears to offer a partial protective effect, modulating the obesogenic impact of air pollution and heat, particularly in low-income settings. Obesity and climate change share common socioeconomic, behavioral, and environmental drivers. Addressing this dual burden requires integrated strategies that promote environmental sustainability and metabolic health. These include green infrastructure, active transportation, climate-adapted clinical care, and public health strategies that reflect planetary health principles. Recognizing obesity not only as a medical condition but also as an environmentally influenced disorder is essential for effective, future-oriented prevention and intervention efforts.

Indexed as

Air PollutionClimate ChangeObesityEnvironmental ExposureGlobal HealthHumansSyndemicUrbanizationAir pollutionBody mass indexClimate changeClimate crisisGlobal warmingHeat stressObesityOverweightThermoregulation

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.