Evidence map›Paper›PMID 41212391›Full record

ReviewHead and neck pathology2025

Subglottic Laryngeal Salivary Gland Intraductal Papillary Mucinous Neoplasm with GNAS Mutation: A Case Report and Review of the Literature.

Benjamin Champion, Benjamin Ryan, Chady Sader, Connull Leslie, Chris Van Vliet

Abstract readCase ReportsReview
In one paragraph

Review in Head and neck pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Benjamin ChampionDepartment of Anatomical Pathology, PathWest QEII Medical Centre, Nedlands, WA, Australia. benjamin.champion@health.wa.gov.au.ORCID http://orcid.org/0009-0005-1668-961X
Benjamin RyanDepartment of Anatomical Pathology, PathWest QEII Medical Centre, Nedlands, WA, Australia.
Chady Sader, Western ENT, Murdoch, WA, Australia.
Connull LeslieDepartment of Anatomical Pathology, PathWest QEII Medical Centre, Nedlands, WA, Australia.
Chris Van VlietDepartment of Anatomical Pathology, PathWest QEII Medical Centre, Nedlands, WA, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSalivary gland intraductal papillary mucinous neoplasm (SG IPMN) is a recently described entity arising predominately from intraoral minor salivary glands, characterised by a low-grade papillary cystic proliferation of mucinous columnar cells, so-named due to its resemblance to the pancreatic duct counterpart [1]. It is currently mentioned in the World Health Organization (WHO) Classification of Tumours (5th edition) salivary gland tumours introduction as a lesion with low-grade mucinous morphology that shares frequent AKT1 mutations with mucinous adenocarcinoma, hence it is thought to represent a low-grade salivary gland mucinous adenocarcinoma and is currently subsumed into this entity [1-3]. However, the classification of the neoplasm remains a controversial issue, with the WHO noting that it is still not established whether SG IPMN should be classified separately or within the mucinous adenocarcinoma spectrum as a potential precursor [2].

methodsWe describe an unusual case of a minor salivary gland papillary mucinous neoplasm presenting in a novel location (subglottic larynx) with a novel mutational driver for this entity (GNAS R844H mutation), and briefly review the literature surrounding SG IPMN, its classification and related tumours.

Indexed as

Adenocarcinoma, MucinousCarcinoma, PapillaryChromograninsGTP-Binding Protein alpha Subunits, GsLaryngeal NeoplasmsSalivary Gland NeoplasmsHumansMutationSalivary Glands, MinorChromograninsGNAS protein, humanGTP-Binding Protein alpha Subunits, GsGNASLarynxSalivary gland intraductal papillary mucinous neoplasm

Identifiers

PMID41212391
PMCPMC12602853

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.