Evidence map›Paper›PMID 41212349›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Barrier-forming lipid solution for severe oral mucositis: effect on oral intake interruption in head and neck cancer.

Takuya Asami, Mai Kim, Keisuke Suzuki, Akie Taniguchi, Sakura Yanagisawa, Masaru Ogawa, Satoshi Yokoo

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Takuya AsamiDepartment of Oral and Maxillofacial Surgery, and Plastic Surgery, Gunma University Graduate School of Medicine, 3-39-22, Showa-Machi, Maebashi, Gunma, 371-8511, Japan.
Mai KimDepartment of Oral and Maxillofacial Surgery, and Plastic Surgery, Gunma University Graduate School of Medicine, 3-39-22, Showa-Machi, Maebashi, Gunma, 371-8511, Japan. kimmu@gunma-u.ac.jp.
Keisuke SuzukiDepartment of Oral and Maxillofacial Surgery, and Plastic Surgery, Gunma University Graduate School of Medicine, 3-39-22, Showa-Machi, Maebashi, Gunma, 371-8511, Japan.
Akie TaniguchiDepartment of Oral and Maxillofacial Surgery, and Plastic Surgery, Gunma University Graduate School of Medicine, 3-39-22, Showa-Machi, Maebashi, Gunma, 371-8511, Japan.
Sakura YanagisawaDepartment of Oral and Maxillofacial Surgery, and Plastic Surgery, Gunma University Graduate School of Medicine, 3-39-22, Showa-Machi, Maebashi, Gunma, 371-8511, Japan.
Masaru OgawaDepartment of Oral and Maxillofacial Surgery, and Plastic Surgery, Gunma University Graduate School of Medicine, 3-39-22, Showa-Machi, Maebashi, Gunma, 371-8511, Japan.
Satoshi YokooDepartment of Oral and Maxillofacial Surgery, and Plastic Surgery, Gunma University Graduate School of Medicine, 3-39-22, Showa-Machi, Maebashi, Gunma, 371-8511, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesOral mucositis (OM) is a localised adverse event of treatment strategies for head and neck cancer, often confined to the irradiated area. Barrier-forming lipid solutions (BLS) have been used to alleviate OM-related symptoms; however, their clinical efficacy remains unclear. This study aimed to evaluate the effects of BLS on OM severity, clinical symptoms, and perioperative nutritional status in patients receiving treatment strategies. PATIENTS AND

methodsThis retrospective study included 200 patients treated with treatment strategies for head and neck cancer at Gunma University Hospital between 2012 and 2021. The patients were categorised into BLS-use and non-use groups. The predictor variables included demographics, smoking and alcohol history, radiation dose, OM severity (common terminology criteria for adverse events [CTCAE] v4.0), and nutritional indices (weight loss rate, serum albumin, prognostic nutritional index [PNI], and modified Glasgow prognostic score[mGPS]) at three time points (pre-treatment, post-treatment, and at discharge). Univariate analysis was performed. Additionally, OM severity, oral intake interruption, and nutritional support (parenteral [PN] or enteral nutrition [EN]) were evaluated among patients with CTCAE Grade 3 OM.

resultsAmong all 200 patients, the BLS-use group showed a significantly shorter duration of oral intake interruption despite receiving a higher radiation dose (both p < 0.001). In the subgroup of 51 patients with Grade 3 OM, the BLS-use group had significantly shorter durations of oral intake interruption, PN (32.0[16.0-42.0]) vs. (75.0[51.0-115.0]) days, p < 0.001), and EN (26.0[15.0-50.0] vs. 47.0[29.0-78.8] days, p = 0.034).

conclusionsBLS use was associated with a reduced duration of oral intake interruption despite higher radiation exposure. In patients with CTCAE Grade 3 OM, BLS use was also associated with shorter durations of parenteral and enteral nutritional support.

Indexed as

Head and Neck NeoplasmsLipidsStomatitisAdultAgedAged, 80 and overEnteral NutritionFemaleHumansMaleMiddle AgedNutritional StatusRetrospective StudiesSeverity of Illness IndexLipidsBarrier-forming lipid solutionHead and neck cancer therapyOral intakeOral mucositis

Identifiers

PMID41212349

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.