ArticleClinical oral investigations2025
Long-term stabilization of universal adhesive interfaces in blood-contaminated dentin by myricetin and resveratrol: MMP inhibition, remineralization, and chemical compatibility with 10-MDP after 12 months.
Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesThis study investigated the application of polyphenols, resveratrol (RES) and myricetin (MYR), to enhance bond durability of phosphoric acid- or sodium hypochlorite-cleaned dentin, along with the potential effects of polyphenols on the bonding performance of 10-methacryloyloxydecyl dihydrogen phosphate (MDP) with dentin. MATERIALS AND
methodsMicrotensile bond strength (µTBS, n = 15 per group), nanoleakage (n = 3 per group), and in situ zymography (n = 3 per group) were evaluated after 24 h of water storage or 15 000 thermocycles plus 12 months of water storage. The potential protective effects of polyphenols in the hybrid layer were analyzed via transmission electron microscopy (TEM, n = 3 per group), X-ray diffraction (XRD, n = 3 per group), and attenuated total reflection Fourier-transform infrared spectroscopy (ATR-FTIR, n = 3 per group). Interactions between MDP and polyphenols and the effect of polyphenols on the chemical affinity of MDP to hydroxyapatite were evaluated using quantum chemical, ultraviolet-visible spectroscopy (UV-vis, n = 3 per group), and FTIR (n = 3 per group) analyses. µTBS data were analyzed with two-way ANOVA and LSD post hoc test, with a significance level of p < 0.05.
resultsAfter 12 months of aging, phosphoric acid and sodium hypochlorite cleaning significantly reduced µTBS and increased nanoleakage. RES and MYR notably improved the aged bond strength and reduced silver ion penetration. In situ zymography revealed that both polyphenols effectively suppressed matrix metalloproteinases (MMPs) activity within the hybrid layer. TEM, XRD, and ATR-FTIR analyses confirmed that the polyphenol-treated groups promoted significant biomimetic remineralization of collagen fibrils.
conclusionsBoth the two polyphenols enhance the dentin bonding durability of phosphoric acid or sodium hypochlorite cleaning by reducing nanoleakage, inhibiting MMPs activity and promoting collagen remineralization, and exhibit chemical compatibility with MDP. CLINICAL RELEVANCE: Phosphoric acid or sodium hypochlorite cleaning decreases dentin bond durability, incorporating polyphenols, RES and MYR, mitigates these adverse effects by enhancing hybrid layer stability.
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