ArticleDiscover oncology2025
A global bibliometric perspective on autophagy and tumor microenvironment in cancer research.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- NCAPG reprograms glycolytic and lipid metabolism by sustaining glycerophospholipid flux in small-cell lung cancer.Molecular and cellular biochemistry · 2026Article
- Unveiling ER-Phagy Receptors in Thyroid Cancer: A Combined Approach of Public Data Mining and In Vitro Validation.Clinical Medicine Insights. Oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAutophagy plays a key role in cell recycling and also has a double-edged sword role in cancer. It serves as a tumor suppressor in the initial phases but eventually maintains stress resistance in cancer cells. Autophagy plays a role in immune cell interactions and cancer-associated fibroblasts within the tumor microenvironment, managing metabolism, immune evasion, and angiogenesis that enable tumor development and drug resistance. Autophagy is, therefore, a major target for cancer therapy.
methodTo investigate the function of autophagy and tumor microenvironment (TME) in cancer progression, we performed a comprehensive search of Scopus and PubMed. We mapped the collaboration network between different journals, countries, institutions, journals, and keywords using VOSviewer (version 1.6.20) and extracted relevant quantitative information.
resultThere is increasing research into autophagy and the TME in cancer, with 3,002 articles showing a consistent annual increase. China and the United States have the highest outputs. "Cancer" is a leading journal in the topic, and "Frontiers in Oncology" is the most cited. Four primary research themes have been highlighted through keyword analysis. Autophagy and the TME play central roles in the diagnosis, prognosis, and treatment of cancer, and natural products and drugs targeting the TME are promising. Nevertheless, manipulating autophagy can result in greater resistance to cancer.
conclusionIn conclusion, our study utilized bibliometric tools to investigate the emerging trend of autophagy and TME in cancer. It is the first extensive bibliometric study to comprehensively map the overlap of autophagy and tumor microenvironment in cancer biology. Our results indicate leading authors, collaborative communities, knowledge gaps, and promising subfields like immunotherapy and hypoxia. The findings provide a strategic guide for future directions in research and therapeutic development in cancer biology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.