ArticleJournal of proteome research2025
Integrative Analysis of Fucosylated Tetra Glycoforms in Hepatocellular Carcinoma: A NanoLC-PRM-MS/MS and Machine Learning Approach.
Chithravel Vadivalagan, Jie Zhang, Jianliang Dai, Suyu Liu, Amit G Singal, Kevin Bass, Neehar D Parikh, David M Lubman
Abstract read
In one paragraphArticle in Journal of proteome research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Chithravel VadivalaganDepartment of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48109, United States.
Jie ZhangDepartment of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48109, United States.
Jianliang DaiDepartment of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States.
Suyu LiuDepartment of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States.
Amit G SingalDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Kevin BassDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Neehar D ParikhDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
David M LubmanDepartment of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48109, United States.ORCID 0000-0001-7731-0232 Funding
Supplemental for Detection of Glycopeptides of MCI in Patient SerumR01CA160254 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David M. Lubman · 2012 to 2026
$5.4MClinical Validation Center for Hepatocellular CarcinomaU01CA271887 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI FASIHA KANWAL, JORGE A MARRERO · 2022 to 2026
$4.7MPrecision Risk Stratification and Screening for HCC among Patients with Indeterminate Liver NodulesU01CA283935 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI HOSHIDA, YUJIN, SINGAL, AMIT · 2023 to 2025
$3.9MProtein Microarrays for the Humoral Response in CancerR01CA106402 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUBMAN, DAVID M. · 2004 to 2008
$1.4MNCI NIH HHS R01 CA106402NCI NIH HHS R01 CA160254NCI NIH HHS U01 CA271887NCI NIH HHS U01 CA283935
6 · The paper itselfAbstract
Hepatocellular carcinoma (HCC), commonly associated with cirrhosis, is a major cause of cancer-related mortality due to its poor prognosis. Herein, we investigated fucosylated glycoforms of serum haptoglobin (Hp) as potential biomarkers for HCC of metabolic associated dysfunction associated liver disease (MASLD) and alcohol related liver disease (ALD) etiologies. We analyzed 119 patient samples, including 60 with cirrhosis and 59 with HCC. Isolated Hp protein was digested using trypsin and Glu-C, and site-specific
Indexed as
Biomarkers, TumorCarcinoma, HepatocellularFucoseHaptoglobinsLiver NeoplasmsAdultAgedalpha-FetoproteinsChromatography, LiquidFemaleGlycosylationHumansLiver CirrhosisMachine LearningMaleMiddle Agedalpha-FetoproteinsBiomarkers, TumorFucoseHaptoglobinsHP protein, humanPolysaccharidesbiomarkerglycoformsHCCmachine learningN-glycansPRM-HCDtetra-antennary
Identifiers
PMID41212027
PMCPMC12701774
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