Enzymatic Oxidation of Carbohydrate Byproducts for Use in Formation of Chitosan Hydrogels.

Owen Mototsune, Yutong Zhang, Durgesh Kavishvar, Arun Ramchandran, Michele C Loewen, Emma Master

Abstract read

In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Enzymatic Oxidation of Carbohydrate Byproducts for Use in Formation of Chitosan Hydrogels.Chembiochem : a European journal of chemical biology · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Owen MototsuneDepartment of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, ON, M5S 3E5, Canada.ORCID https://orcid.org/0009-0001-2703-4337

Yutong ZhangDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, 30 Marie Curie, Ottawa, ON, K1N 6N5, Canada.

Durgesh KavishvarDepartment of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, ON, M5S 3E5, Canada.

Arun RamchandranDepartment of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, ON, M5S 3E5, Canada.

Michele C LoewenDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, 30 Marie Curie, Ottawa, ON, K1N 6N5, Canada.

Emma MasterDepartment of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, ON, M5S 3E5, Canada.ORCID https://orcid.org/0000-0002-6837-9817

Funding

Canada Excellence Research Chairs, Government of Canada 950-231567HORIZON EUROPE Framework 964764Natural Sciences and Engineering Research Council of Canada 402005Natural Sciences and Engineering Research Council of Canada 528163Natural Sciences and Engineering Research Council of Canada ALLRP 570676-2021

6 · The paper itself

Abstract

Chitosan hydrogels are used in diverse applications ranging from pharmaceuticals and biomedical materials to food and agriculture. This study introduces a biology-inspired approach to create fully bio-based hydrogels by combining chitosan with bio-based di/polycarbonyl crosslinkers produced through the enzymatic oxidation of carbohydrates. Two such crosslinkers, Ox-XOS and Ox-Lac, were synthesized by oxidizing carbohydrates: Ox-XOS was produced by oxidizing xylooligosaccharides (XOS) with pyranose dehydrogenase from Agaricus bisporus (AbPDH1), and Ox-Lac was produced by oxidizing lactose (Lac) with galactose oxidase from Fusarium graminearum (FgrGalOx). The efficacy of enzymatic oxidation of lactose and XOS was analyzed using liquid chromatography and mass spectroscopy, showing high degrees of oxidation, and carbonyl groups were confirmed using ATR-FTIR and

Indexed as

ChitosanGalactose OxidaseGlucuronatesHydrogelsOligosaccharidesAgaricusFusariumLactoseOxidation-ReductionChitosanGalactose OxidaseGlucuronatesHydrogelsLactoseOligosaccharidesxylooligosaccharidechitosancrosslinkergalactose oxidasehydrogelpyranose dehydrogenasexylooligosaccharides

Identifiers

PMID41211803

DOI10.1002/cbic.202500559

PMCPMC12703462

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.