ArticleTherapeutic advances in respiratory disease
Clinical implications of bronchoalveolar lavage fluid cellular analysis in fibrotic interstitial lung disease combined with CT quantification.
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Abstract
backgroundAlthough the clinical role of bronchoalveolar lavage (BAL) in interstitial lung disease (ILD) has been suggested by previous studies, its clinical utility remains debatable.
objectivesWe aimed to evaluate the clinical implications of combining quantitative computed tomography (QCT) and BAL fluid cellular analysis in patients with fibrotic ILD.
designThis study was a retrospective, single-center study.
methodsWe analyzed patients with fibrotic ILD who underwent BAL in specific lung locations and used deep-learning-based QCT. Correlations between BAL cellular components and QCT parameters were assessed for both the whole lung and the tested lobe, and survival outcomes and disease progression were evaluated.
resultsAmong 163 patients, no significant difference was observed in BAL cellular analysis between radiologic usual interstitial pneumonia (UIP) and non-UIP groups (for all,
conclusionAlthough BAL fluid cellular analysis alone does not differentiate radiologic patterns or offer prognostic values, elevated BAL neutrophil levels combined with a high fibrosis score on CT may help to identify patients at higher risk of early fibrosis progression.
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